{"title":"用于癌细胞检测的光子晶体光纤等离子体生物传感器","authors":"Arun Kumar Shukla, Ratneshwar Kumar Ratnesh, Dhruva Chaudhary","doi":"10.1007/s11468-025-02993-7","DOIUrl":null,"url":null,"abstract":"<div><p>A highly sensitive surface plasmon resonance (SPR)-based photonic crystal fiber (PCF) sensor is proposed for advanced biosensing applications. Designed to precisely distinguish the sensitivity peaks of different analytes, the sensor’s performance has been extensively evaluated using COMSOL Multiphysics software with the finite volume finite element method (FVFEM). Noble metals such as gold, silver, tin, and nickel are employed for SPR excitation due to their excellent chemical stability and inertness. To further enhance the SPR effect, the integration of graphene and other 2D nanomaterials has been explored. These materials offer remarkable electrical, optical, and surface properties, including high surface area and strong light–matter interactions, making them ideal for improving sensor sensitivity and selectivity. Recent studies also highlight the growing importance of 2D nanomaterials in enhancing SPR-based biosensing, particularly in biomedical applications. In this study, silver and tin were selected along with silica, and their sensor responses were compared. The sensor features symmetrically placed air holes and an analyte space in the outer region for easy sample injection. Simulation results indicate that the tin-based design performs best within a refractive index range of 1.33 to 1.38, while the silver-based design is optimal between 1.35 and 1.4. Both designs achieve a wavelength sensitivity of 5000 nm/RIU for X-polarization core mode with a resolution of 2 × 10<sup>−6</sup> RIU. The maximum amplitude sensitivity recorded was 1313.47 RIU<sup>−1</sup> for silver and 1130 RIU<sup>−1</sup> for tin. Biocompatible plasmonic sensors are gaining attention due to their potential in biomedical detection, including proteins, DNA, and cancer markers. The proposed sensor is designed with future applications in mind, particularly for cancer cell detection and monitoring disease progression. In the future, such biosensors could enable real-time monitoring of cancer stages, improving early diagnosis and treatment strategies.</p></div>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":"20 8","pages":"5945 - 5956"},"PeriodicalIF":4.3000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photonic Crystal Fiber-Based Plasmonic Biosensor for Cancer Cell Detection\",\"authors\":\"Arun Kumar Shukla, Ratneshwar Kumar Ratnesh, Dhruva Chaudhary\",\"doi\":\"10.1007/s11468-025-02993-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A highly sensitive surface plasmon resonance (SPR)-based photonic crystal fiber (PCF) sensor is proposed for advanced biosensing applications. Designed to precisely distinguish the sensitivity peaks of different analytes, the sensor’s performance has been extensively evaluated using COMSOL Multiphysics software with the finite volume finite element method (FVFEM). Noble metals such as gold, silver, tin, and nickel are employed for SPR excitation due to their excellent chemical stability and inertness. To further enhance the SPR effect, the integration of graphene and other 2D nanomaterials has been explored. These materials offer remarkable electrical, optical, and surface properties, including high surface area and strong light–matter interactions, making them ideal for improving sensor sensitivity and selectivity. Recent studies also highlight the growing importance of 2D nanomaterials in enhancing SPR-based biosensing, particularly in biomedical applications. In this study, silver and tin were selected along with silica, and their sensor responses were compared. The sensor features symmetrically placed air holes and an analyte space in the outer region for easy sample injection. Simulation results indicate that the tin-based design performs best within a refractive index range of 1.33 to 1.38, while the silver-based design is optimal between 1.35 and 1.4. Both designs achieve a wavelength sensitivity of 5000 nm/RIU for X-polarization core mode with a resolution of 2 × 10<sup>−6</sup> RIU. The maximum amplitude sensitivity recorded was 1313.47 RIU<sup>−1</sup> for silver and 1130 RIU<sup>−1</sup> for tin. Biocompatible plasmonic sensors are gaining attention due to their potential in biomedical detection, including proteins, DNA, and cancer markers. The proposed sensor is designed with future applications in mind, particularly for cancer cell detection and monitoring disease progression. In the future, such biosensors could enable real-time monitoring of cancer stages, improving early diagnosis and treatment strategies.</p></div>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":\"20 8\",\"pages\":\"5945 - 5956\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11468-025-02993-7\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1007/s11468-025-02993-7","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Photonic Crystal Fiber-Based Plasmonic Biosensor for Cancer Cell Detection
A highly sensitive surface plasmon resonance (SPR)-based photonic crystal fiber (PCF) sensor is proposed for advanced biosensing applications. Designed to precisely distinguish the sensitivity peaks of different analytes, the sensor’s performance has been extensively evaluated using COMSOL Multiphysics software with the finite volume finite element method (FVFEM). Noble metals such as gold, silver, tin, and nickel are employed for SPR excitation due to their excellent chemical stability and inertness. To further enhance the SPR effect, the integration of graphene and other 2D nanomaterials has been explored. These materials offer remarkable electrical, optical, and surface properties, including high surface area and strong light–matter interactions, making them ideal for improving sensor sensitivity and selectivity. Recent studies also highlight the growing importance of 2D nanomaterials in enhancing SPR-based biosensing, particularly in biomedical applications. In this study, silver and tin were selected along with silica, and their sensor responses were compared. The sensor features symmetrically placed air holes and an analyte space in the outer region for easy sample injection. Simulation results indicate that the tin-based design performs best within a refractive index range of 1.33 to 1.38, while the silver-based design is optimal between 1.35 and 1.4. Both designs achieve a wavelength sensitivity of 5000 nm/RIU for X-polarization core mode with a resolution of 2 × 10−6 RIU. The maximum amplitude sensitivity recorded was 1313.47 RIU−1 for silver and 1130 RIU−1 for tin. Biocompatible plasmonic sensors are gaining attention due to their potential in biomedical detection, including proteins, DNA, and cancer markers. The proposed sensor is designed with future applications in mind, particularly for cancer cell detection and monitoring disease progression. In the future, such biosensors could enable real-time monitoring of cancer stages, improving early diagnosis and treatment strategies.
期刊介绍：
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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