Yuan Li
(, ), Yifeng Xi
(, ), Xiaofei Wang
(, ), Zengsheng Chen
(, )
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Mathematical model for qualitative assessment of blood pump-induced thrombosis and stroke risk
To guide clinical treatment and optimize blood pump design, a mathematical model was developed to evaluate thrombosis and stroke risks induced by blood pumps. Incorporating platelet receptor synthesis/shedding and von Willebrand factor (vWF) unfolding/degradation under shear stress, the model assessed hemorrhagic stroke risk based on shear stress-impaired platelet-vWF binding and thrombosis risk through shear stress-enhanced platelet-vWF interactions leading to hypercoagulability and blood stagnation. The model was validated using three blood pumps—HeartWare, HeartMate II, and HeartMate 3—showing consistency with clinical evidence. Thrombosis risk ranked as HeartMate II > HeartWare > HeartMate 3, primarily due to blood stagnation and shear stress-induced hypercoagulability. Hemorrhagic and ischemic stroke risks followed the ranking HeartWare > HeartMate II > HeartMate 3, with ischemic stroke regions overlapping shear stress and thrombosis-prone regions. Reducing narrow clearances and stagnation regions and avoiding regions of overlapping high shear stress and prolonged residence time can enhance hemocompatibility. The model accurately identified high-risk regions for thrombosis and stroke, providing insights for optimizing blood pump design and clinical strategies.
期刊介绍：
Acta Mechanica Sinica, sponsored by the Chinese Society of Theoretical and Applied Mechanics, promotes scientific exchanges and collaboration among Chinese scientists in China and abroad. It features high quality, original papers in all aspects of mechanics and mechanical sciences.
Not only does the journal explore the classical subdivisions of theoretical and applied mechanics such as solid and fluid mechanics, it also explores recently emerging areas such as biomechanics and nanomechanics. In addition, the journal investigates analytical, computational, and experimental progresses in all areas of mechanics. Lastly, it encourages research in interdisciplinary subjects, serving as a bridge between mechanics and other branches of engineering and the sciences.
In addition to research papers, Acta Mechanica Sinica publishes reviews, notes, experimental techniques, scientific events, and other special topics of interest.
Related subjects » Classical Continuum Physics - Computational Intelligence and Complexity - Mechanics
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