1例严重白血病视网膜病变的外科治疗

Q3 Medicine

American Journal of Ophthalmology Case Reports Pub Date : 2025-09-01 DOI:10.1016/j.ajoc.2025.102417

Farzad Jamshidi , Timothy M. Boyce , R. Christopher Bowen , H. Culver Boldt , Elaine M. Binkley

{"title":"1例严重白血病视网膜病变的外科治疗","authors":"Farzad Jamshidi , Timothy M. Boyce , R. Christopher Bowen , H. Culver Boldt , Elaine M. Binkley","doi":"10.1016/j.ajoc.2025.102417","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>To present a case of severe leukemic retinopathy requiring surgical rehabilitation. We report four-year follow up and associated post-remission pathology including cystoid macular edema (CME) and retinal ischemia.</div></div><div><h3>Observations</h3><div>This is a case report of a 35-year-old female with acute myelocytic leukemia (AML) who presented with hand motions (HM) vision in both eyes and severe multilayered hemorrhages. She underwent pars plana vitrectomy (PPV) in the left eye and subsequent PPV with internal limiting membrane (ILM) peel in the right eye after autologous bone marrow transplant. After cataract surgery and treatment of CME, visual acuity improved to 20/25 in each eye. Fundus examination and optical coherence tomography (OCT) revealed outer retinal loss outside of the fovea.</div></div><div><h3>Conclusions and importance</h3><div>Surgical intervention can be necessary for visual rehabilitation in some patients with leukemic retinopathy. With improved medical treatment for AML, patients survive longer, making visual rehabilitation more impactful and allowing for a better understanding of the natural history of leukemic retinopathy.</div></div>","PeriodicalId":7569,"journal":{"name":"American Journal of Ophthalmology Case Reports","volume":"39 ","pages":"Article 102417"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Surgical management of a case of severe leukemic retinopathy\",\"authors\":\"Farzad Jamshidi , Timothy M. Boyce , R. Christopher Bowen , H. Culver Boldt , Elaine M. Binkley\",\"doi\":\"10.1016/j.ajoc.2025.102417\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>To present a case of severe leukemic retinopathy requiring surgical rehabilitation. We report four-year follow up and associated post-remission pathology including cystoid macular edema (CME) and retinal ischemia.</div></div><div><h3>Observations</h3><div>This is a case report of a 35-year-old female with acute myelocytic leukemia (AML) who presented with hand motions (HM) vision in both eyes and severe multilayered hemorrhages. She underwent pars plana vitrectomy (PPV) in the left eye and subsequent PPV with internal limiting membrane (ILM) peel in the right eye after autologous bone marrow transplant. After cataract surgery and treatment of CME, visual acuity improved to 20/25 in each eye. Fundus examination and optical coherence tomography (OCT) revealed outer retinal loss outside of the fovea.</div></div><div><h3>Conclusions and importance</h3><div>Surgical intervention can be necessary for visual rehabilitation in some patients with leukemic retinopathy. With improved medical treatment for AML, patients survive longer, making visual rehabilitation more impactful and allowing for a better understanding of the natural history of leukemic retinopathy.</div></div>\",\"PeriodicalId\":7569,\"journal\":{\"name\":\"American Journal of Ophthalmology Case Reports\",\"volume\":\"39 \",\"pages\":\"Article 102417\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Ophthalmology Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2451993625001707\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Ophthalmology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451993625001707","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

目的报告一例需要手术康复的严重白血病视网膜病变。我们报告了四年的随访和相关的缓解后病理，包括囊样黄斑水肿（CME）和视网膜缺血。这是一个35岁的女性急性髓细胞白血病（AML）的病例报告，她表现为双眼手部运动（HM）视力和严重的多层出血。自体骨髓移植后，左眼行玻璃体切除（PPV），右眼行玻璃体切除合并内限制膜剥离（ILM）。白内障手术和治疗后，每只眼睛的视力提高到20/25。眼底检查和光学相干断层扫描（OCT）显示中央凹外视网膜丢失。结论及重要性：对于部分白血病视网膜病变患者，手术干预是必要的。随着AML医学治疗的改进，患者存活时间更长，使视力康复更有影响，并使人们更好地了解白血病视网膜病变的自然史。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Surgical management of a case of severe leukemic retinopathy

Purpose

To present a case of severe leukemic retinopathy requiring surgical rehabilitation. We report four-year follow up and associated post-remission pathology including cystoid macular edema (CME) and retinal ischemia.

Observations

This is a case report of a 35-year-old female with acute myelocytic leukemia (AML) who presented with hand motions (HM) vision in both eyes and severe multilayered hemorrhages. She underwent pars plana vitrectomy (PPV) in the left eye and subsequent PPV with internal limiting membrane (ILM) peel in the right eye after autologous bone marrow transplant. After cataract surgery and treatment of CME, visual acuity improved to 20/25 in each eye. Fundus examination and optical coherence tomography (OCT) revealed outer retinal loss outside of the fovea.

Conclusions and importance

Surgical intervention can be necessary for visual rehabilitation in some patients with leukemic retinopathy. With improved medical treatment for AML, patients survive longer, making visual rehabilitation more impactful and allowing for a better understanding of the natural history of leukemic retinopathy.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

American Journal of Ophthalmology Case Reports Medicine-Ophthalmology

CiteScore

2.40

自引率

0.00%

发文量

513

审稿时长

16 weeks

期刊介绍： The American Journal of Ophthalmology Case Reports is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished case report manuscripts directed to ophthalmologists and visual science specialists. The cases shall be challenging and stimulating but shall also be presented in an educational format to engage the readers as if they are working alongside with the caring clinician scientists to manage the patients. Submissions shall be clear, concise, and well-documented reports. Brief reports and case series submissions on specific themes are also very welcome.