抑制分子堆叠使近红外过二亚胺光敏剂具有平衡的能量耗散途径，用于肿瘤光动力治疗

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-08-30 DOI:10.1016/j.dyepig.2025.113195

Chao Fu , Wei Zhao , Hongmian Yu, Xiruo Li, Jiayi Li, Guoqi Chen, Yuli Yin, Rong Hu

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引用次数: 0

摘要

具有近红外（NIR）发射的有机光敏剂的构建在精确治疗方面显示出巨大的前景。然而，荧光成像和光疗效果依赖于相互竞争的光物理过程，因此设计具有明显发光（特别是在近红外光区）并能高效地将能量转化为有价值的活性氧的光敏剂仍然是一个巨大的挑战。本文报道了一系列基于苝酰二亚胺（PDI）的简单近红外光敏剂，通过调节给体-受体-给体共轭主链中苯基部分的位置，实现了扭曲分子结构与有效π共轭之间的填充平衡。光动力学性质观察表明，所制备的荧光团具有良好的光敏能力，在光照射下产生I型和II型活性氧（ROS），并基于铁凋亡机制实现对肿瘤细胞的清除。此外，近红外区的明亮发射使得体内肺转移的敏感检测成为可能。这些结果为图像引导肿瘤光动力治疗应用提供了具有启发性的近红外光敏剂设计策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Frustrated molecular stacking enables NIR perylenediimide photosensitizers with balanced energy dissipation pathways for tumor photodynamic therapy

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Frustrated molecular stacking enables NIR perylenediimide photosensitizers with balanced energy dissipation pathways for tumor photodynamic therapy

The construction of organic photosensitizers with near infrared (NIR) emission has shown great promise for precise therapeutic applications. However, fluorescence imaging and phototherapy efficacy are dependent on competitive photophysical processes, so it is still a great challenge to engineer photosensitizer with appreciable light emission especially in the NIR light region, and highly efficient energy conversion into valuable reactive oxygen species. In this paper, we report series of simple perylene diimide (PDI)-based NIR photosensitizers by regulating the position of a phenyl moiety in the donor-acceptor-donor conjugated backbone, a packing balance between the twisted molecular structure and effective π-conjugation is actualized. Photodynamic property observation reveals that the developed fluorophores present desirable photosensitizing ability with the production of both type I and II reactive oxygen species (ROS) under light irradiation, and the eradication of tumor cells is realized based on ferroptosis mechanism. Moreover, the bright emission in NIR region allows for the sensitive detection of pulmonary metastasis in vivo. These results provide an illuminating NIR photosensitizers design strategy for image-guided tumor photodynamic therapy applications.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.