与抗干扰素γ自身抗体相关的弥散性哥伦比亚分枝杆菌感染1例报告并文献复习

IF 1.8 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-08-28 DOI:10.1016/j.diagmicrobio.2025.117087

Dan Zhou, Yi Xie, Yuling Xiao

{"title":"与抗干扰素γ自身抗体相关的弥散性哥伦比亚分枝杆菌感染1例报告并文献复习","authors":"Dan Zhou, Yi Xie, Yuling Xiao","doi":"10.1016/j.diagmicrobio.2025.117087","DOIUrl":null,"url":null,"abstract":"<div><div>A 46-year-old male presented with multifocal osteolytic lesions and rash. mNGS of clavicular biopsy identified <em>M.colombiense</em>, confirmed by culture and MALDI-TOF MS. Initial improvement with clarithromycin-based therapy was followed by relapse post-trauma, coinciding with anti-interferon-γ autoantibody detection and new-onset diabetes. Despite negative follow-up cultures, imaging and clinical response supported reactivation.</div></div>","PeriodicalId":11329,"journal":{"name":"Diagnostic microbiology and infectious disease","volume":"114 1","pages":"Article 117087"},"PeriodicalIF":1.8000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Disseminated mycobacterium colombiense infection associated with anti-interferon-γ autoantibody: a case report and literature review\",\"authors\":\"Dan Zhou, Yi Xie, Yuling Xiao\",\"doi\":\"10.1016/j.diagmicrobio.2025.117087\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A 46-year-old male presented with multifocal osteolytic lesions and rash. mNGS of clavicular biopsy identified <em>M.colombiense</em>, confirmed by culture and MALDI-TOF MS. Initial improvement with clarithromycin-based therapy was followed by relapse post-trauma, coinciding with anti-interferon-γ autoantibody detection and new-onset diabetes. Despite negative follow-up cultures, imaging and clinical response supported reactivation.</div></div>\",\"PeriodicalId\":11329,\"journal\":{\"name\":\"Diagnostic microbiology and infectious disease\",\"volume\":\"114 1\",\"pages\":\"Article 117087\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diagnostic microbiology and infectious disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0732889325004109\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic microbiology and infectious disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0732889325004109","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

46岁男性，多局灶性溶骨病变及皮疹。锁骨活检的mNGS鉴定出哥伦比亚分枝杆菌，经培养和MALDI-TOF ms证实。最初通过克拉霉素治疗得到改善，随后创伤后复发，同时检测到抗干扰素-γ自身抗体和新发糖尿病。尽管随访培养阴性，影像学和临床反应支持再激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Disseminated mycobacterium colombiense infection associated with anti-interferon-γ autoantibody: a case report and literature review

A 46-year-old male presented with multifocal osteolytic lesions and rash. mNGS of clavicular biopsy identified M.colombiense, confirmed by culture and MALDI-TOF MS. Initial improvement with clarithromycin-based therapy was followed by relapse post-trauma, coinciding with anti-interferon-γ autoantibody detection and new-onset diabetes. Despite negative follow-up cultures, imaging and clinical response supported reactivation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.