{"title":"用机械微铣削制造絮凝剂测试用微流控芯片","authors":"Parvathi K K, Nithin Tom Mathew","doi":"10.1007/s10404-025-02843-2","DOIUrl":null,"url":null,"abstract":"<div><p>The fabrication of microfluidic chips using mechanical micromilling offers a promising method for rapid prototyping. This study investigates the use of mechanical micromilling to produce microchannels in Polymethyl methacrylate for flocculant testing, which requires precision and smooth surfaces to ensure effective fluid flow and mixing. The dimensional accuracy of the fabricated microchannels was evaluated using a coordinate measuring machine, and surface quality was analysed through scanning electron microscopy and confocal microscopy. The coordinate measuring measurements indicated high consistency across most features, but significant deviations were observed in specific regions, suggesting challenges in achieving tight tolerances for certain geometric features. The scanning electron micrographs analysis revealed surface imperfections, including excess burrs and feed marks, which could negatively impact fluid flow in microchannels. Confocal microscopy confirmed the presence of high surface roughness, with pronounced peaks and valleys that could disrupt flow and increase resistance in microfluidic applications. The findings highlight the need to optimise process parameters to improve surface quality. Optimisation of the micromilling parameters and post-processing techniques is necessary to enhance surface quality for the microfluidic device to meet the stringent requirements necessary for effective flocculant testing.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":"29 9","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fabrication of a microfluidic chip using mechanical micromilling for flocculant testing\",\"authors\":\"Parvathi K K, Nithin Tom Mathew\",\"doi\":\"10.1007/s10404-025-02843-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The fabrication of microfluidic chips using mechanical micromilling offers a promising method for rapid prototyping. This study investigates the use of mechanical micromilling to produce microchannels in Polymethyl methacrylate for flocculant testing, which requires precision and smooth surfaces to ensure effective fluid flow and mixing. The dimensional accuracy of the fabricated microchannels was evaluated using a coordinate measuring machine, and surface quality was analysed through scanning electron microscopy and confocal microscopy. The coordinate measuring measurements indicated high consistency across most features, but significant deviations were observed in specific regions, suggesting challenges in achieving tight tolerances for certain geometric features. The scanning electron micrographs analysis revealed surface imperfections, including excess burrs and feed marks, which could negatively impact fluid flow in microchannels. Confocal microscopy confirmed the presence of high surface roughness, with pronounced peaks and valleys that could disrupt flow and increase resistance in microfluidic applications. The findings highlight the need to optimise process parameters to improve surface quality. Optimisation of the micromilling parameters and post-processing techniques is necessary to enhance surface quality for the microfluidic device to meet the stringent requirements necessary for effective flocculant testing.</p></div>\",\"PeriodicalId\":706,\"journal\":{\"name\":\"Microfluidics and Nanofluidics\",\"volume\":\"29 9\",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microfluidics and Nanofluidics\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10404-025-02843-2\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INSTRUMENTS & INSTRUMENTATION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microfluidics and Nanofluidics","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10404-025-02843-2","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INSTRUMENTS & INSTRUMENTATION","Score":null,"Total":0}
Fabrication of a microfluidic chip using mechanical micromilling for flocculant testing
The fabrication of microfluidic chips using mechanical micromilling offers a promising method for rapid prototyping. This study investigates the use of mechanical micromilling to produce microchannels in Polymethyl methacrylate for flocculant testing, which requires precision and smooth surfaces to ensure effective fluid flow and mixing. The dimensional accuracy of the fabricated microchannels was evaluated using a coordinate measuring machine, and surface quality was analysed through scanning electron microscopy and confocal microscopy. The coordinate measuring measurements indicated high consistency across most features, but significant deviations were observed in specific regions, suggesting challenges in achieving tight tolerances for certain geometric features. The scanning electron micrographs analysis revealed surface imperfections, including excess burrs and feed marks, which could negatively impact fluid flow in microchannels. Confocal microscopy confirmed the presence of high surface roughness, with pronounced peaks and valleys that could disrupt flow and increase resistance in microfluidic applications. The findings highlight the need to optimise process parameters to improve surface quality. Optimisation of the micromilling parameters and post-processing techniques is necessary to enhance surface quality for the microfluidic device to meet the stringent requirements necessary for effective flocculant testing.
期刊介绍:
Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include:
1.000 Fundamental principles of micro- and nanoscale phenomena like,
flow, mass transport and reactions
3.000 Theoretical models and numerical simulation with experimental and/or analytical proof
4.000 Novel measurement & characterization technologies
5.000 Devices (actuators and sensors)
6.000 New unit-operations for dedicated microfluidic platforms
7.000 Lab-on-a-Chip applications
8.000 Microfabrication technologies and materials
Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).