植物鞘氨醇多种合成方法的研究进展

IF 8.8 2区 化学 Q1 Chemistry
Hangyu Bai, Shuguang Yang, Zhaoyu Wang, Yisheng Zhao, Ying Xu, Yanxin Zhang
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引用次数: 0

摘要

鞘磷脂是鞘脂的一种,因其具有抗炎、抗癌和免疫调节等多种生物活性而受到广泛关注。这些生物活性脂质主要存在于植物中,在细胞信号传导和膜结构中起着至关重要的作用。近年来,由于药理学研究和药物开发对植物鞘苷等鞘脂分子的需求不断增加,化学合成这些分子已成为有机化学研究的一个主要热点。鞘氨醇的合成已被广泛报道,并且相对容易实现。然而,由于存在额外的手性中心,植物鞘氨醇的合成更为复杂,导致合成方法的多样性更大。本文综述了近年来植物鞘氨醇及其类似物的合成方法,包括不对称合成和手性助剂和催化剂的全合成。本文综述了近年来植物鞘苷和其他鞘脂类化合物的化学合成进展,为研究植物鞘苷和其他鞘脂类化合物的生物活性和合成方面的研究提供了有价值的资料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent Progress in the Diverse Synthetic Approaches to Phytosphingosine

Recent Progress in the Diverse Synthetic Approaches to Phytosphingosine

Recent Progress in the Diverse Synthetic Approaches to Phytosphingosine

Phytosphingosine, a type of sphingolipids, has gained significant attention due to their diverse biological activities, including anti-inflammatory, anticancer, and immunomodulatory properties. These bioactive lipids, predominantly found in plant sources, play crucial roles in cellular signaling and membrane structure. In recent years, the chemical synthesis of phytosphingosine and other sphingolipids have become a major focus in organic chemistry due to the increasing demand for these molecules in pharmacological research and drug development. The synthesis of sphingosine has been extensively reported and is relatively straightforward to implement. However, the synthesis of phytosphingosine is more complex due to the presence of additional chiral centers, leading to a greater diversity of synthetic methods. This review provides a comprehensive overview of the recent advancements in synthetic methodologies for phytosphingosine and its analogs, including asymmetric synthesis and total synthesis using chiral auxiliaries and catalysts. By summarizing recent chemical synthesis advancements, this review serves as a valuable resource for researchers interested in the biological activities and synthetic aspects of phytosphingosine and other sphingolipids.

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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry 化学-化学综合
CiteScore
11.70
自引率
1.20%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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