澳大利亚记忆临床队列中颞肌厚度与虚弱的关系

IF 3.4 3区 医学 Q2 GERIATRICS & GERONTOLOGY
Andrew L. H. Huynh, Sophia Avramoudas, James Andrews, Nan Jordan, Paul Yates
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引用次数: 0

摘要

背景:肌肉减少症和虚弱与认知障碍相关,两者都与不良临床结果相关。目前对肌肉减少症的评估并没有在记忆诊所常规进行。颞肌厚度(TMT)可以通过常规记忆临床脑磁共振成像(MRI)测量,已被提出作为肌肉减少症的替代生物标志物。然而,TMT和虚弱之间的联系以前并没有被阐明。目的探讨在记忆临床队列中,冠状t1加权脑MRI测量的TMT与使用衰弱指数(FI)评估的衰弱之间的关系。方法对2014年在澳大利亚墨尔本某三级转诊医院记忆门诊就诊的140例患者进行回顾性队列研究。收集具有足够冠状t1加权脑MRI用于评估的患者的TMT和FI。比较体弱(FI≥0.25)和非体弱患者的TMT。结果140例患者,中位年龄75.3岁(四分位间距[IQR] 67.1-83.2岁),55%为女性。中位TMT为5.5 mm (IQR 4.4-6.8 mm), 34%虚弱。与身体不虚弱的人相比,身体虚弱的人更有可能变老(p < 0.001), MMSE更低(p = 0.003), TMT厚度更小(p = 0.011)。讨论和结论:在该队列中,冠状t1加权脑MRI测量的TMT减少与虚弱相关。未来的研究将纳入肌肉减少症的其他测量(如DXA,动态测量),以验证TMT在冠状t1加权脑MRI中的应用是有必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of temporalis muscle thickness and frailty in an Australian memory clinic cohort

Background

Sarcopenia and frailty are associated with cognitive impairment, and both are associated with adverse clinical outcomes. Current assessments of sarcopenia are not routinely performed in memory clinics. Temporalis muscle thickness (TMT), which can be measured on routine memory clinic brain magnetic resonance imaging (MRI), has been proposed as a surrogate biomarker of sarcopenia. However, the association of TMT and frailty has not been previously elucidated.

Aims

To explore the relationship between TMT, measured on coronal T1-weighted brain MRI and frailty, as assessed using a Frailty Index (FI), in a memory clinic cohort.

Methods

Retrospective cohort study of 140 patients who attended a memory clinic in a tertiary referral hospital in Melbourne, Australia in 2014. TMT and FI of patients with an adequate coronal T1-weighted brain MRI for assessment were collected. Comparisons of TMT between frail (FI ≥ 0.25) and non-frail patients were explored.

Results

140 patients, median age 75.3 years old (interquartile range [IQR] 67.1–83.2 years old), 55% female. The median TMT was 5.5 mm (IQR 4.4–6.8 mm) and 34% were frail. People who were frail were more likely to be older (p < 0.001), have a lower MMSE (p = 0.003), and reduced TMT thickness (p = 0.011) compared to people who were not frail.

Discussion and conclusion

Reduced TMT, measured in coronal T1-weighted brain MRI is associated with frailty in this cohort. Future studies incorporating additional measures of sarcopenia (e.g. DXA, dynamometry) to validate the use of TMT in coronal T1-weighted brain MRI are warranted.

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来源期刊
CiteScore
7.90
自引率
5.00%
发文量
283
审稿时长
1 months
期刊介绍: Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.
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