基于适体体的靶向药物传递和疾病治疗在临床前和临床应用

IF 17.6 1区医学 Q1 PHARMACOLOGY & PHARMACY

Advanced drug delivery reviews Pub Date : 2025-08-29 DOI:10.1016/j.addr.2025.115680

Weihong Yang , Chunyan Ran , Xinran Lian , Zehua Wang , Zhen Du , Tao Bing , Yu Zhang , Weihong Tan

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引用次数: 0

摘要

精准医学的出现迫切需要先进的药物靶向策略和精细的药物输送系统。适配体具有特殊的亲和力和特异性、低分子量、可忽略的免疫原性、显著的稳定性、成本效益和结构通用性等特点，在临床前研究和临床应用中都是靶向治疗的有希望的候选者。本文综述了基于适配体的治疗策略的最新进展，包括三个关键应用领域：直接治疗剂、靶向配体工程和药物控制释放。我们将总结适配体在各种疾病治疗中的临床前应用，包括眼病、癌症、凝血和炎症。特别强调的是新兴的临床阶段适体疗法正在对这些疾病进行严格的评估。此外，我们将讨论适体临床转化和商业化的潜在挑战和无限机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Aptamer-based targeted drug delivery and disease therapy in preclinical and clinical applications

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Aptamer-based targeted drug delivery and disease therapy in preclinical and clinical applications

The advent of precision medicine has created an urgent need for advanced drug-targeting strategies and refined drug delivery systems. Aptamers, characterized by their exceptional affinity and specificity, low molecular weight, negligible immunogenicity, remarkable stability, cost-effectiveness, and structural versatility, are emerging as promising candidates in targeted therapeutics, both in preclinical research and clinical applications. This review provides a comprehensive analysis of the latest advancements in aptamer-based therapeutic strategies, encompassing three key application domains: direct therapeutic agents, targeted ligand engineering, and controlled drug release. We will summarize the preclinical applications of aptamers for various disease therapies, including eye disorders, cancers, coagulation, and inflammation. Particular emphasis is placed on emerging clinical-stage aptamer therapeutics undergoing rigorous evaluation for these diseases. Furthermore, we will discuss the potential challenges and unlimited opportunities for the clinical transformation and commercialization of aptamers.

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来源期刊

Advanced drug delivery reviews 医学-药学

CiteScore

28.10

自引率

5.00%

发文量

294

审稿时长

15.1 weeks

期刊介绍： The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery. In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.