血浆持久性有机污染物与老年人脑萎缩、认知能力下降和痴呆风险的关系

IF 9.7 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-09-01 DOI:10.1016/j.envint.2025.109756

Sophie Lefèvre-Arbogast , Pierre Scala , Aurore Zorilla , Catherine Helmer , Jade Chaker , Arthur David , Fabien Mercier , Cécilia Samieri

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引用次数: 0

摘要

持久性有机污染物（POP），包括多氯联苯（PCBs）和有机氯农药，是实验模型中确定的神经毒物；然而，目前还不确定普通人群是否会增加患脑老化疾病的风险。我们在以人群为基础的老年人队列中评估了血浆POP浓度与三种痴呆相关结果的前瞻性关联。方法分析包括来自三城研究的515名参与者，在血液测量时基线无痴呆（1999-2000年，平均年龄72.5岁），他们在17 年期间接受了多达8次认知功能和痴呆的重复评估，在10 年期间接受了多达3次神经影像学检查。采用气相色谱-串联质谱法测定15种多氯联苯、12种有机氯农药和1种溴化阻燃剂的血浆浓度（检出率≥5 %），并通过析因分析得出总结总体暴露的POP评分。使用Cox和线性混合模型分析与痴呆风险、认知功能（四项测试的复合测量）和脑容量（内侧颞叶）的纵向变化的关系，并根据基线年龄、性别、教育程度、载脂蛋白E （APOE）基因型、体重指数和总脂质浓度进行调整。结果在多变量调整模型中，个体POPs和总POP得分与痴呆相关结局均无显著一致的相关性。APOE基因型与高氯化多氯联苯（同源基因180、194和196-203）之间在所有结果中均观察到显著的相互作用（相互作用p≤0.05），APOE- 4等位基因携带者与高氯化多氯联苯呈负相关，而非携带者则相反。总的来说，这项前瞻性研究并没有提供强有力的证据来支持在普通人群中暴露于持久性有机污染物与老年人患全因痴呆、认知能力下降或脑萎缩风险之间存在不利关联。

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Associations of plasma persistent organic pollutants with brain atrophy, cognitive decline and risk of dementia in older adults

Background

Persistent Organic Pollutants (POP), including polychlorinated biphenyls (PCBs) and organochlorine pesticides, are established neurotoxicants in experimental models; yet it remains uncertain whether exposures in the general population increase the risk to develop brain aging pathologies. We assessed the prospective associations of plasma POP concentrations with three dementia-related outcomes in a population-based cohort of older adults.

Methods

Analyses included 515 participants from the Three-City Study, free of dementia at baseline at the time of blood measurements (1999–2000, mean age 72.5), who underwent up to 8 repeated assessments of cognitive function and dementia over 17 years and up to 3 neuroimaging examinations over 10 years. Plasma concentrations of 15 PCBs, 12 organochlorine pesticides and 1 brominated flame retardant were measured by gas chromatography coupled with tandem mass spectrometry (detection rate ≥5 %), and a POP score summarizing overall exposure was derived via factorial analysis. Associations with dementia risk, longitudinal changes in cognitive function (composite measure of four tests) and in brain volume (medial temporal lobe) were analyzed using Cox and linear mixed models, adjusted for baseline age, sex, education, apolipoprotein E (APOE) genotype, body mass index and total lipid concentrations.

Results

In multivariable-adjusted models, neither individual POPs nor the total POP score were significantly and consistently associated with dementia-related outcomes. Significant interactions were observed between APOE genotype and highly-chlorinated PCBs (congeners 180, 194, and 196–203) across all outcomes (p for interaction ≤0.05), whereby adverse associations were seen in carriers of the APOE-ɛ4 allele, whereas opposing trends were observed in non-carriers.

Conclusion

Overall, this prospective study does not provide robust evidence to support an adverse association between exposure to POPs in the general population and the risk of all-cause dementia, cognitive decline, or brain atrophy in older adults.

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.