{"title":"铜-壳聚糖催化的环保Biginelli反应","authors":"Magda H. Abdellattif, Chou-Yi Hsu, Munthar Kadhim Abosaoda, Ashok Kumar Bishoyi, Suhas Ballal, Manal Morad Karim, Abhayveer Singh, S. Supriya, Rajashree Panigrahi","doi":"10.1007/s11164-025-05645-x","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, one of the most unique green catalysts named Cu-Picolin-Chitosan-mTEG was designed, synthesized and analyzed using different methods such as XRD, FESEM, TEM, TGA, FTIR, EDX-EDS, DLS, and ICP analyses. After confirming of synthesized nanocomposite, it is tested in oxidation of various alcohols to aldehyde and the insitu formed aldehydes are condensed with thiourea and 4‑hydroxycumarin. Finally, the synthesis of nine new thioxochromenopyrimidine derivatives by Cu-Picolin-Chitosan-mTEG is examined in perfect yields from alcohol derivatives. The conditions for reaction are green, and water is used as a solvent. This protocol offers several notable advantages, such as cost-effectiveness, atom economy, low catalyst loading, green oxidants, mild conditions, high yields, and recyclability of the nanocomposite over five cycles. Notably, this is the first report on the use of this nanocomposite for the synthesis of thioxochromenopyrimidine derivatives.</p></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"51 9","pages":"5059 - 5078"},"PeriodicalIF":3.5000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Eco-friendly Biginelli reaction via copper–chitosan catalyst\",\"authors\":\"Magda H. Abdellattif, Chou-Yi Hsu, Munthar Kadhim Abosaoda, Ashok Kumar Bishoyi, Suhas Ballal, Manal Morad Karim, Abhayveer Singh, S. Supriya, Rajashree Panigrahi\",\"doi\":\"10.1007/s11164-025-05645-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this study, one of the most unique green catalysts named Cu-Picolin-Chitosan-mTEG was designed, synthesized and analyzed using different methods such as XRD, FESEM, TEM, TGA, FTIR, EDX-EDS, DLS, and ICP analyses. After confirming of synthesized nanocomposite, it is tested in oxidation of various alcohols to aldehyde and the insitu formed aldehydes are condensed with thiourea and 4‑hydroxycumarin. Finally, the synthesis of nine new thioxochromenopyrimidine derivatives by Cu-Picolin-Chitosan-mTEG is examined in perfect yields from alcohol derivatives. The conditions for reaction are green, and water is used as a solvent. This protocol offers several notable advantages, such as cost-effectiveness, atom economy, low catalyst loading, green oxidants, mild conditions, high yields, and recyclability of the nanocomposite over five cycles. Notably, this is the first report on the use of this nanocomposite for the synthesis of thioxochromenopyrimidine derivatives.</p></div>\",\"PeriodicalId\":753,\"journal\":{\"name\":\"Research on Chemical Intermediates\",\"volume\":\"51 9\",\"pages\":\"5059 - 5078\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research on Chemical Intermediates\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11164-025-05645-x\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research on Chemical Intermediates","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11164-025-05645-x","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Eco-friendly Biginelli reaction via copper–chitosan catalyst
In this study, one of the most unique green catalysts named Cu-Picolin-Chitosan-mTEG was designed, synthesized and analyzed using different methods such as XRD, FESEM, TEM, TGA, FTIR, EDX-EDS, DLS, and ICP analyses. After confirming of synthesized nanocomposite, it is tested in oxidation of various alcohols to aldehyde and the insitu formed aldehydes are condensed with thiourea and 4‑hydroxycumarin. Finally, the synthesis of nine new thioxochromenopyrimidine derivatives by Cu-Picolin-Chitosan-mTEG is examined in perfect yields from alcohol derivatives. The conditions for reaction are green, and water is used as a solvent. This protocol offers several notable advantages, such as cost-effectiveness, atom economy, low catalyst loading, green oxidants, mild conditions, high yields, and recyclability of the nanocomposite over five cycles. Notably, this is the first report on the use of this nanocomposite for the synthesis of thioxochromenopyrimidine derivatives.
期刊介绍：
Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry.
The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
