分化型肝细胞癌体外三维球体模型剪接变异鉴定的简要报告

IF 3.2 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Clinical and Experimental Hepatology Pub Date : 2025-08-09 DOI:10.1016/j.jceh.2025.103151

Shreyas H. Karunakara, Rohit Mehtani, Gopalakrishna Ramaswamy, Vinutha S. Puttamallapa, Prashant M. Vishwanath, Prasanna K. Santhekadur

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引用次数: 0

摘要

肝细胞癌（HCC）是原发性肝癌的主要形式。选择性剪接事件（ASEs）对于产生mRNA剪接变异体至关重要，这些变异体可以在HCC发展过程中决定细胞命运。我们在体外肝细胞癌球形三维模型中报道了不同的ase。这个简短的研究可以作为一个模板来设计针对不同亚型肝细胞癌中不同剪接事件的功能研究。

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A Brief Report on Identification of Splice Variants in an In Vitro 3D Spheroid Model for Differentiated Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) represents the major form of primary liver cancer. Alternative splicing events (ASEs) are critical to generating mRNA splice variants that can dictate cell fate during HCC development. We report different ASEs in a 3D in vitro HCC spheroid model. This short study serves as a template to design functional studies to target different splicing events in different subtypes of hepatocellular carcinoma.

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