文献中首次报道的克里米亚-刚果出血热再感染：相隔11年

IF 1.8 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-08-22 DOI:10.1016/j.diagmicrobio.2025.117075

Seyit Ali Büyüktuna , Yasemin Çakır Kıymaz , Caner Öksüz , Murtaza Öz , Cihad Baysal , Nazif Elaldı

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引用次数: 0

摘要

克里米亚-刚果出血热（CCHF）是一种病毒性人畜共患病，在包括乌克兰在内的几个地区流行。虽然一般认为感染CCHFV可获得长期免疫，但这种保护的持久性和机制尚不清楚。在这里，我们报告了首例pcr确认的CCHFV再感染病例，发生在首次发病11年后，患者来自土耳其Sivas高流行区。第二次发作症状较轻，无出血表现，提示有一定程度的部分免疫保护。该病例挑战了关于CCHFV终生免疫的现有假设，并强调需要进一步研究流行环境中的再感染动力学和免疫记忆。

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The first reported Crimean–Congo hemorrhagic fever reinfection in the literature: 11 years apart

Crimean-Congo Hemorrhagic Fever (CCHF) is a viral zoonosis endemic to several regions, including Türkiye. Although it is generally assumed that CCHFV infection confers long-lasting immunity, the durability and mechanisms of this protection remain unclear. Here, we report the first PCR-confirmed reinfection case of CCHFV, occurring 11 years after the initial episode, in a patient from the hyperendemic region of Sivas, Turkiye. The second episode presented with milder symptoms and no hemorrhagic findings, suggesting a degree of partial immune protection. This case challenges existing assumptions about lifelong immunity to CCHFV and highlights the need for further studies on reinfection dynamics and immune memory in endemic settings.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.