动作观察训练对多发性硬化症患者手功能、上肢力量及疲劳的影响

IF 2.9 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2025-08-27 DOI:10.1016/j.ibneur.2025.08.021

Fatemeh Savaedi , Omid Anbiyaee , Akram Ansari , Fatemeh chichagi , Nazanin Moeini , Eftekhar Azarm , Mahsa Fadavighaffari , Sara Khosravi , Meimanat Akbari

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引用次数: 0

摘要

多发性硬化症（MS）是一种影响中枢神经系统的慢性自身免疫性疾病，经常导致上肢损伤，严重影响日常生活活动和生活质量。动作观察训练（AOT）是一种利用镜像神经元系统提高运动能力的新型神经康复方法。本研究旨在评估AOT对多发性硬化症患者手部功能、握力和疲劳的改善效果。方法采用非随机、单盲临床试验，将30例多发性硬化症患者分为干预组（AOT联合标准物理治疗）和对照组（标准物理治疗）。使用多发性硬化症问卷（AMSQ）评估主要结局。次要目标包括握力和夹紧力（通过动力测量法评估）和疲劳严重程度量表（FSS）。在基线和干预四周后进行评估。采用协方差分析（ANCOVA）对数据进行评估，p为 <； 0.05，具有显著性。结果干预组在AMSQ评分（调整平均差值= - 29.5，±4.5 SE, p <； 0.05）、握力（MD = 10.54，±3.20 SE，患手p = 0.003）、捏紧力（MD = 1.46，±0.45 SE，患手p = 0.003）和疲劳（MD = - 9.60，±4.13 SE, p = 0.028）方面均较对照组有显著改善。结论AOT可显著改善MS患者的手部功能、握力和疲劳水平，提示其有可能成为一种有效的康复工具。未来的研究应检查辅助辅助治疗的持久优势及其与其他神经康复方法的融合。

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Effect of action observation training on hand function, upper extremity strength and fatigue in individuals with multiple sclerosis

Background

Multiple sclerosis (MS) is a chronic autoimmune condition that affects the central nervous system, frequently resulting in upper limb impairment, which considerably affects activities of daily living and quality of life. Action Observation Training (AOT) is a novel neurorehabilitation method that utilizes the mirror neuron system to improve motor performance. This study aimed to evaluate the effectiveness of AOT in improving hand function, grip strength, and reducing fatigue in individuals with MS.

Methods

A non-randomized, single-blind clinical experiment was conducted involving 30 multiple sclerosis patients, who were allocated to either an intervention group (AOT in conjunction with standard physical therapy) or a control group (standard physical therapy alone). The primary outcome was evaluated utilizing the Arm Function in Multiple Sclerosis Questionnaire (AMSQ). Secondary objectives included grip and pinch strength (assessed by dynamometry) and Fatigue Severity Scale (FSS). Evaluations were conducted at baseline and following four weeks of intervention. Data were evaluated utilizing Analysis of Covariance (ANCOVA) with significance established at p < 0.05.

Results

The intervention group showed significantly greater improvements in AMSQ scores (adjusted mean difference = −29.5, ± 4.5 SE, p < 0.05), power grip strength (MD = 10.54, ± 3.20 SE, p = 0.003 for the affected hand), pinch strength (MD = 1.46, ± 0.45 SE, p = 0.003 for the affected hand), and fatigue (MD = −9.60, ± 4.13 SE, p = 0.028), compared to the control group. These findings suggest that AOT is an effective intervention for improving upper limb function and reducing fatigue in individuals with MS.

Conclusion

AOT significantly improves hand function, grip strength, and fatigue levels in individuals with MS, suggesting its potential as an effective rehabilitation tool. Future investigations should examine the enduring advantages of AOT and its amalgamation with alternative neurorehabilitation methodologies.

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