骨骼肌的液-液相分离：肌肉生物学的新前沿

IF 2.1 3区生物学 Q2 DEVELOPMENTAL BIOLOGY

Developmental biology Pub Date : 2025-08-19 DOI:10.1016/j.ydbio.2025.08.016

Mingfu Xiong , Yun Chen , Shilong Wang , Zhaobo Zhang , Danyang Fan , Jiaying Li , Xia He , Yongsheng Zhang , Yilong Yao

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引用次数: 0

摘要

液-液相分离（LLPS）是一个重要的生物物理过程，它使细胞内的动态区隔成为可能，在最近的细胞组织研究中得到了突出的地位。然而，它对骨骼肌（运动和代谢调节的重要组织）的影响在很大程度上仍是未知的。这篇综述强调了最近关于LLPS在其他组织中的作用的见解，同时研究了它在骨骼肌发育、再生和疾病中的潜在功能。通过综合现有知识，我们提出探索骨骼肌中的LLPS可以揭示肌肉生理学的基本方面，并为肌肉相关疾病提供创新的治疗途径。因此，对LLPS的深入了解可能会改变我们对骨骼肌病变的理解和治疗。

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Liquid–liquid phase separation (LLPS) in skeletal muscle: A new frontier in muscle biology

Liquid–liquid phase separation (LLPS) is a crucial biophysical process that enables dynamic compartmentalization within cells, gaining prominence in recent research on cellular organization. However, its implications for skeletal muscle—a vital tissue for movement and metabolic regulation—remain largely uncharted. This review highlights recent insights into LLPS's roles in other tissues while examining its potential functions in skeletal muscle development, regeneration, and disease. By synthesizing existing knowledge, we propose that exploring LLPS in skeletal muscle could uncover fundamental aspects of muscle physiology and offer innovative therapeutic avenues for muscle-related disorders. A deeper grasp of LLPS may thus transform our understanding and treatment of skeletal muscle pathologies.

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来源期刊

Developmental biology 生物-发育生物学

CiteScore

5.30

自引率

3.70%

发文量

182

审稿时长

1.5 months

期刊介绍： Developmental Biology (DB) publishes original research on mechanisms of development, differentiation, and growth in animals and plants at the molecular, cellular, genetic and evolutionary levels. Areas of particular emphasis include transcriptional control mechanisms, embryonic patterning, cell-cell interactions, growth factors and signal transduction, and regulatory hierarchies in developing plants and animals.