老年人握力和健康衰老的蛋白质组学特征：英国生物银行的前瞻性队列研究

IF 7.4 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition Pub Date : 2025-08-23 DOI:10.1016/j.clnu.2025.08.024

Zhong-Yue Liu , Jing Yang , Fei Fang , Yong-Gang Hao , Xiu-Ying Cai , Meng-Yuan Miao , Jie-Qiong Lyu , Ji-Mei Gu , Yu-Wen Qian , Zhong-Xiao Wan , Li-Qiang Qin , Qi Fang , Guo-Chong Chen

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引用次数: 0

摘要

虽然握力（GS）被认为是各种健康结果的可行预测指标，但其与健康衰老的关系以及血浆蛋白的作用尚不清楚。方法我们纳入了27,828名64岁及以上的明显健康的成年人，他们在最近的随访中有资格生存到80岁。健康老龄化被定义为在随访期间存活至80岁且无重大慢性疾病（mcd）。多变量Logistic回归模型评估绝对或相对GS与健康老龄化可能性的关系。在3366名参与者中，鉴定了GS的血浆蛋白质组学特征，并进一步评估了它们对GS-健康衰老关系的中介作用。结果共16844人（60.5%）实现健康老龄化。在多变量调整后，较高的绝对和相对GS水平分别与67%（95%置信区间[CI]: 50% - 88%）和92%（95%置信区间[CI]: 75% - 110%）高的健康老龄化可能性相关。与绝对和相对GS均呈同一方向相关的蛋白有298种（向上20种，向下278种），与健康衰老显著相关的蛋白有50种（13种为正相关，37种为负相关）。这50种蛋白中的大多数在GS与健康衰老的关系中表现出中介作用，可能涉及细胞因子-细胞因子受体相互作用、病毒蛋白与细胞因子受体相互作用以及趋化因子信号通路。结论：高GS与健康衰老的可能性相关，部分是通过调节循环蛋白参与炎症和免疫反应途径。

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Proteomic signatures of grip strength and healthy aging among older adults: A prospective cohort study in the UK Biobank

Background

While grip strength (GS) is recognized as a feasible predictor of various health outcomes, its association with healthy aging and the role of plasma proteins remain unclear.

Methods

We included 27,828 apparently healthy adults aged 64 years or older who were eligible to survive to age 80 as of the latest follow-up. Healthy aging was defined as survival to age 80 without developing major chronic diseases (MCDs) during the follow-up. Multivariable Logistic regression models assessed the relationship of absolute or relative GS with the likelihood of healthy aging. In a subset of 3366 participants, plasma proteomic signatures of GS were identified and their mediating effects on the GS-healthy aging relationship were further assessed.

Results

In total, 16,844 (60.5 %) participants achieved healthy aging. After multivariable adjustment, higher levels of absolute and relative GS were associated with a 67 % (95 % confidence interval [CI]: 50 %–88 %) and a 92 % (95 % CI: 75 %–110 %) higher likelihood of healthy aging, respectively. There were 298 proteins related to both absolute and relative GS in the same direction (20 upwards and 278 downwards), with 50 proteins showing significant associations (13 positive and 37 inverse) with healthy aging. The majority of these 50 proteins showed mediating effects on the relationship of GS with healthy aging, potentially involving cytokine-cytokine receptor interaction, viral protein interactions with cytokine receptor, and the chemokine signaling pathway.

Conclusions

Greater GS is associated with a higher likelihood of healthy aging, partially through the modulation of circulating proteins involving the pathways of inflammation and immunity responses.

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.