17世纪诊断鼠疫的骆驼来自罗马尼亚沿着历史丝绸之路

IF 2.6 4区医学 Q3 INFECTIOUS DISEASES

Infection Genetics and Evolution Pub Date : 2025-08-22 DOI:10.1016/j.meegid.2025.105814

Hamadou Oumarou Hama , Mahmoud Boualam , Jean Armengaud , Michel Drancourt , Gérard Aboudharam , Adrian Bălășescu , Valentin Radu

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引用次数: 0

摘要

研究人员通过牙髓古基因组学和古蛋白质组学，对从罗马尼亚一处17世纪丝绸之路遗址发掘出的6头骆驼以及阴性对照进行了盲目调查，以寻找包括鼠疫病原体鼠疫耶尔森菌在内的假结核耶尔森菌复体的痕迹。在样品R04（1条）和R05（2条）中检测到特异的reads，同时也检测到鼠疫杆菌特异性的16S rRNA鸟嘌呤转移酶和另一个假结核杆菌复合物肽。综上所述，这些经过验证的数据诊断了这些古骆驼的鼠疫，这些古骆驼可能在中世纪和现代欧洲大流行期间参与了鼠疫沿着古丝绸之路的传播。

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Diagnosing plague in 17th century camelids from Romania along historical Silk Routes

Six camels exhumed from a 17th-century Silk Route site in Romania, along with negative controls, were blindly investigated via dental pulp paleometagenomics and paleoproteomics for traces of Yersinia pseudotuberculosis complex including the plague agent Yersinia pestis. Specific reads were detected in sample R04 (one read) and R05 (two reads) which also yielded a 16S rRNA guanine transferase specific for Y. pestis and one other Y. pseudotuberculosis complex peptide. Taken together, these validated data diagnosed plague in these ancient camels which likely participated in plague dissemination along ancient Silk Routes during the large Medieval and Modern Times pandemic in Europe.

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来源期刊

Infection Genetics and Evolution 医学-传染病学

CiteScore

8.40

自引率

0.00%

发文量

215

审稿时长

82 days

期刊介绍： (aka Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases -- MEEGID) Infectious diseases constitute one of the main challenges to medical science in the coming century. The impressive development of molecular megatechnologies and of bioinformatics have greatly increased our knowledge of the evolution, transmission and pathogenicity of infectious diseases. Research has shown that host susceptibility to many infectious diseases has a genetic basis. Furthermore, much is now known on the molecular epidemiology, evolution and virulence of pathogenic agents, as well as their resistance to drugs, vaccines, and antibiotics. Equally, research on the genetics of disease vectors has greatly improved our understanding of their systematics, has increased our capacity to identify target populations for control or intervention, and has provided detailed information on the mechanisms of insecticide resistance. However, the genetics and evolutionary biology of hosts, pathogens and vectors have tended to develop as three separate fields of research. This artificial compartmentalisation is of concern due to our growing appreciation of the strong co-evolutionary interactions among hosts, pathogens and vectors. Infection, Genetics and Evolution and its companion congress [MEEGID](http://www.meegidconference.com/) (for Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases) are the main forum acting for the cross-fertilization between evolutionary science and biomedical research on infectious diseases. Infection, Genetics and Evolution is the only journal that welcomes articles dealing with the genetics and evolutionary biology of hosts, pathogens and vectors, and coevolution processes among them in relation to infection and disease manifestation. All infectious models enter the scope of the journal, including pathogens of humans, animals and plants, either parasites, fungi, bacteria, viruses or prions. The journal welcomes articles dealing with genetics, population genetics, genomics, postgenomics, gene expression, evolutionary biology, population dynamics, mathematical modeling and bioinformatics. We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .