{"title":"异质造血的发育起源","authors":"Shaokang Mo, Kuangyu Yen","doi":"10.1002/ajh.70050","DOIUrl":null,"url":null,"abstract":"Hematopoietic stem and progenitor cells (HSPCs) are initially generated during embryogenesis, laying the foundation for the hematopoietic system. These embryonic HSPCs exhibit functional heterogeneity, which is essential for their diverse roles in both fetal and adult hematopoiesis. Growing evidence suggests that this heterogeneity arises from hemogenic endothelium (HE), a specialized subset of endothelial precursors with hematopoietic potential. Additionally, studies show that hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitors (MPPs) emerge independently from HE, with notable contributions from non‐endothelial sources. This review explores the spatiotemporal heterogeneity of HE and discusses how this diversity contributes to the emergence of HSPCs. We propose an integrated framework that refines current models by highlighting the regional and temporal variations in HE that drive HSPC diversification. By synthesizing current knowledge, this review offers novel insights into the origins of hematopoietic diversity and the factors that govern HE differentiation.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"1 1","pages":""},"PeriodicalIF":9.9000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Developmental Origins of the Heterogeneous Hematopoiesis\",\"authors\":\"Shaokang Mo, Kuangyu Yen\",\"doi\":\"10.1002/ajh.70050\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hematopoietic stem and progenitor cells (HSPCs) are initially generated during embryogenesis, laying the foundation for the hematopoietic system. These embryonic HSPCs exhibit functional heterogeneity, which is essential for their diverse roles in both fetal and adult hematopoiesis. Growing evidence suggests that this heterogeneity arises from hemogenic endothelium (HE), a specialized subset of endothelial precursors with hematopoietic potential. Additionally, studies show that hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitors (MPPs) emerge independently from HE, with notable contributions from non‐endothelial sources. This review explores the spatiotemporal heterogeneity of HE and discusses how this diversity contributes to the emergence of HSPCs. We propose an integrated framework that refines current models by highlighting the regional and temporal variations in HE that drive HSPC diversification. By synthesizing current knowledge, this review offers novel insights into the origins of hematopoietic diversity and the factors that govern HE differentiation.\",\"PeriodicalId\":7724,\"journal\":{\"name\":\"American Journal of Hematology\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":9.9000,\"publicationDate\":\"2025-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Hematology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ajh.70050\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ajh.70050","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
造血干细胞和祖细胞(Hematopoietic stem and progenitor cells, HSPCs)最初是在胚胎发育过程中产生的,为造血系统奠定了基础。这些胚胎造血干细胞表现出功能异质性,这是它们在胎儿和成人造血中的不同作用所必需的。越来越多的证据表明,这种异质性来自于造血内皮(HE),一种具有造血潜能的内皮前体细胞的特殊亚群。此外,研究表明造血干细胞(hsc)和多能造血祖细胞(mpp)的出现独立于HE,非内皮来源的贡献显著。本文探讨了HE的时空异质性,并讨论了这种多样性如何促进HSPCs的出现。我们提出了一个综合框架,通过强调推动HSPC多样化的HE的区域和时间变化来改进当前模型。通过综合现有的知识,本综述为造血多样性的起源和控制HE分化的因素提供了新的见解。
Developmental Origins of the Heterogeneous Hematopoiesis
Hematopoietic stem and progenitor cells (HSPCs) are initially generated during embryogenesis, laying the foundation for the hematopoietic system. These embryonic HSPCs exhibit functional heterogeneity, which is essential for their diverse roles in both fetal and adult hematopoiesis. Growing evidence suggests that this heterogeneity arises from hemogenic endothelium (HE), a specialized subset of endothelial precursors with hematopoietic potential. Additionally, studies show that hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitors (MPPs) emerge independently from HE, with notable contributions from non‐endothelial sources. This review explores the spatiotemporal heterogeneity of HE and discusses how this diversity contributes to the emergence of HSPCs. We propose an integrated framework that refines current models by highlighting the regional and temporal variations in HE that drive HSPC diversification. By synthesizing current knowledge, this review offers novel insights into the origins of hematopoietic diversity and the factors that govern HE differentiation.
期刊介绍:
The American Journal of Hematology offers extensive coverage of experimental and clinical aspects of blood diseases in humans and animal models. The journal publishes original contributions in both non-malignant and malignant hematological diseases, encompassing clinical and basic studies in areas such as hemostasis, thrombosis, immunology, blood banking, and stem cell biology. Clinical translational reports highlighting innovative therapeutic approaches for the diagnosis and treatment of hematological diseases are actively encouraged.The American Journal of Hematology features regular original laboratory and clinical research articles, brief research reports, critical reviews, images in hematology, as well as letters and correspondence.