人类中的抗菌体SIR2

IF 27.6 1区 医学 Q1 IMMUNOLOGY
Paula Jauregui
{"title":"人类中的抗菌体SIR2","authors":"Paula Jauregui","doi":"10.1038/s41590-025-02271-y","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 9","pages":"1425-1425"},"PeriodicalIF":27.6000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antiphage SIR2 in humans\",\"authors\":\"Paula Jauregui\",\"doi\":\"10.1038/s41590-025-02271-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":19032,\"journal\":{\"name\":\"Nature Immunology\",\"volume\":\"26 9\",\"pages\":\"1425-1425\"},\"PeriodicalIF\":27.6000,\"publicationDate\":\"2025-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41590-025-02271-y\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41590-025-02271-y","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

最近的研究已经确定了特定真核生物和细菌免疫蛋白之间的同源性联系。在《科学》杂志上的一项研究中,Bonhomme等人发现了沉默信息调节因子2 (SIR2)的人类同源物,SIR2是细菌抗菌体系统中存在的一种蛋白质结构域,在toll样受体(TLR)途径中起作用。通过基于同源性的SIR2蛋白检测和系统发育分析,他们在生命之树中发现了两个不同的SIR2结构域蛋白亚家族——sirtuins(具有管家功能)和SIRim(一种未表征的免疫蛋白家族)。在人类SIRim亚家族中,作者发现FAM118B(更名为SIRal)在TLR通路中对先天免疫激活很重要,在小鼠和人类细胞模型中上调干扰素刺激基因和促炎细胞因子。SIRal被证明可以限制单纯疱疹病毒1型和肠沙门氏菌在巨噬细胞中的复制。作者发现SIRim蛋白在真核生物中广泛存在,并表明斑马鱼体内SIRim有助于对迟发爱德华菌的免疫反应。细菌SIR2蛋白是nadase,作者表明来自不同分支的真核SIRim蛋白,包括人类SIRal,可以在体外使用NAD+。这项工作表明,在生命之树中利用比较免疫学可以帮助发现以前未知或未表征的人类免疫蛋白。原始参考文献:Science 389, eadr8536 (2025)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antiphage SIR2 in humans
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nature Immunology
Nature Immunology 医学-免疫学
CiteScore
40.00
自引率
2.30%
发文量
248
审稿时长
4-8 weeks
期刊介绍: Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信