肾脏中致病性线粒体DNA突变的积累

IF 39.8 1区 医学 Q1 UROLOGY & NEPHROLOGY
Ellen F. Carney
{"title":"肾脏中致病性线粒体DNA突变的积累","authors":"Ellen F. Carney","doi":"10.1038/s41581-025-01002-8","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":19059,"journal":{"name":"Nature Reviews Nephrology","volume":"21 10","pages":"649-649"},"PeriodicalIF":39.8000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Accumulation of pathogenic mitochondrial DNA mutations in the kidney\",\"authors\":\"Ellen F. Carney\",\"doi\":\"10.1038/s41581-025-01002-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":19059,\"journal\":{\"name\":\"Nature Reviews Nephrology\",\"volume\":\"21 10\",\"pages\":\"649-649\"},\"PeriodicalIF\":39.8000,\"publicationDate\":\"2025-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Nephrology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41581-025-01002-8\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Nephrology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41581-025-01002-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

线粒体DNA (mtDNA)的致病性突变通常是异质性的:单个细胞内可以存在野生型和突变型mtDNA,当突变型mtDNA的比例超过阈值时,遗传缺陷就会出现。蒋敏及其同事的一项研究为肾细胞mtDNA异质性和线粒体肾病的发病机制提供了新的见解。“足细胞表现出累积mtDNA突变的倾向,而高突变负荷的管状上皮细胞(TECs)则表现出mtDNA拷贝数的增加,这表明细胞行为的根本差异,”Jiang说。“这些观察结果表明,即使在同一器官内,个体细胞类型也可能对mtDNA异质性表现出不同的反应。这种现象可能不是肾脏独有的,强调了在单细胞水平上分析突变负荷的必要性。”
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Accumulation of pathogenic mitochondrial DNA mutations in the kidney

Accumulation of pathogenic mitochondrial DNA mutations in the kidney
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信