Tuomas Lehtinen, Luayo Zhang, Kristina Sundquist, Jan Sundquist, Tim Waterboer, Matti Lehtinen, Kari Hemminki
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引用次数: 0
摘要
人乳头瘤病毒（HPV）感染与扁桃体和舌底鳞状细胞癌（TSCC/BOTSCC）有关。我们使用瑞典家庭数据库评估患有肛门生殖器癌的女性的丈夫患TSCC/BOTSCC的相对风险（RR）。瑞典家庭数据库包括自1932年以来确定的350万个家庭和1600万个人，并与1958年至2015年的癌症数据相关。我们探讨了诊断为肛门生殖器（肛门、外阴/阴道、宫颈）癌或原位宫颈癌（CIS）的妇女的丈夫与对照组的丈夫相比，TSCC/BOTSCC的风险比。结果浸润性肛门生殖器官癌患者的丈夫TSCC/BOTSCC的RR随时间推移和诊断年龄的降低而升高。2002-2015年，50岁诊断的TSCC/BOTSCC病例的RR最高为5.35 （95% CI 2.21-13.0）。在CIS女性的丈夫中，TSCC/BOTSCC的RR是2倍，与时间无关。结论：配偶中hpv相关侵袭性癌症风险增加的聚类似乎与日历时间有关。这在癌症科学中引入了一个新的视角：家族性hpv相关癌症风险在配偶中增加。
Elevated Risk of HPV-Associated Oropharyngeal Cancers in Husbands of Women With Anogenital Cancer
Introduction
Human papillomavirus (HPV) infection is associated with tonsillar and base-of-tongue squamous cell carcinomas (TSCC/BOTSCC). We evaluated the relative risk (RR) of TSCC/BOTSCC in the husbands of women with anogenital cancer using the Swedish family database.
Methods
The Swedish family database includes 3.5 million families and 16 million individuals identified since 1932 and linked to cancer data from 1958 to 2015. We explored the RR of TSCC/BOTSCC in husbands of women diagnosed with anogenital (anal, vulvar/vaginal, cervical) cancer or cervical carcinoma in situ (CIS) as compared to husbands of controls.
Results
The RR of TSCC/BOTSCC in husbands of women with invasive anogenital cancer increased by calendar time and decreasing ages at diagnoses. In 2002–2015, the RR peaked at 5.35 (95% CI 2.21–13.0) in TSCC/BOTSCC cases diagnosed at age < 50 years. In husbands of women with CIS, the RR for TSCC/BOTSCC was 2-fold irrespective of time period.
Conclusions
Clustering of increased HPV-associated invasive cancer risk in spouses appears to be calendar-time dependent. This introduces a new perspective in cancer science: an increase of familial HPV-associated cancer risk in spouses.
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