外伤性髓鞘少突胶质细胞糖蛋白抗体视神经炎1例

Q3 Medicine

American Journal of Ophthalmology Case Reports Pub Date : 2025-08-20 DOI:10.1016/j.ajoc.2025.102409

Saif A. Hamdan , Jamie A. Nassur , Sarah Thornton

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引用次数: 0

摘要

目的髓鞘少突胶质细胞糖蛋白（MOG）抗体相关疾病（MOGAD）最近被区分为独立于其他脱髓鞘疾病的疾病实体。本病例报告强调了眼眶外伤与MOG抗体（MOG- igg）视神经炎发展的可能关联。31岁男性，无明显眼部病史，摩托车撞车后4周右眼视力模糊。右眼检查发现视力明显下降，眼底镜检查发现瞳孔进行性缺损，周围椎间盘升高。广泛的检查，包括影像学和血清学，显示视神经炎阳性MOG-IgG抗体滴度。患者接受静脉注射类固醇治疗，随后口服逐渐减少，症状几乎完全缓解。结论和重要性：在创伤后出现疼痛性视力丧失的患者中，应考虑脑电图抗体相关视神经炎，因为早期识别和治疗可导致良好的结果。

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Post-traumatic myelin oligodendrocyte glycoprotein antibody optic neuritis: A case report

Purpose

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) has recently been distinguished as its own disease entity separate from other demyelinating diseases. This case report highlights the possible association of orbital trauma with the development of MOG antibody (MOG-IgG) optic neuritis.

Observations

A 31-year-old male with no significant ocular history presented with blurry vision in the right eye four weeks after a motorcycle crash. Right eye examination was notable for a significant decrease in visual acuity with a relative afferent pupillary defect and circumferential disc elevation on fundoscopy. An extensive workup, including imaging and serology, revealed optic neuritis with a positive MOG-IgG antibody titer. The patient was treated with intravenous steroids followed by an oral taper, with near-complete resolution of his symptoms.

Conclusions and importance

MOG antibody-related optic neuritis should be considered in patients presenting with painful vision loss after trauma, as early recognition and treatment can lead to favorable outcomes.

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来源期刊

American Journal of Ophthalmology Case Reports Medicine-Ophthalmology

CiteScore

2.40

自引率

0.00%

发文量

513

审稿时长

16 weeks

期刊介绍： The American Journal of Ophthalmology Case Reports is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished case report manuscripts directed to ophthalmologists and visual science specialists. The cases shall be challenging and stimulating but shall also be presented in an educational format to engage the readers as if they are working alongside with the caring clinician scientists to manage the patients. Submissions shall be clear, concise, and well-documented reports. Brief reports and case series submissions on specific themes are also very welcome.