形式[4+2]环加成法合成外消旋菌素B及其衍生物

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-08-21 DOI:10.1016/j.tetlet.2025.155798

Bhuvana Narasimman

引用次数: 0

摘要

本文提出了一种简洁高效的吲哚咔唑支架的合成方法，即通过2,3 ' -双吲哚与亲二酚的[4+2]环加成一步合成吲哚咔唑支架。此外，该方法合成外消旋菌素B生物碱的时间短，不需要采用保护和去保护策略，产率适中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of racemosin B and its derivatives via formal [4+2] cycloaddition

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Synthesis of racemosin B and its derivatives via formal [4+2] cycloaddition

A concise and efficient method has been developed for the synthesis of the indolocarbazole scaffold via a formal [4+2] cycloaddition of 2,3′-biindole with dienophiles in a single step. Further, this method offers a short synthesis of racemosin B alkaloid without employing a protection and deprotection strategy with moderate yield.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.