{"title":"自由基铜催化三组分氧化还原-中性烯烃双官能化","authors":"Zhiming Feng , Jincai Zheng , Wei Zhou , Cong-Ying Zhou , Chengming Wang","doi":"10.1016/j.tchem.2025.100144","DOIUrl":null,"url":null,"abstract":"<div><div>Three-component olefin difunctionalization represents a powerful strategy for constructing complex organic molecules. However, its advancement has been constrained by persistent challenges in chemoselectivity, environmental sustainability, and cost efficiency. The synergistic integration of cost-effective copper catalysis with radical chemistry offers a promising approach to address these limitations. This review provides a comprehensive analysis of copper-catalyzed, redox-neutral three-component olefin difunctionalization reactions, systematically examining both the diverse reaction types and their underlying mechanisms.</div></div>","PeriodicalId":74918,"journal":{"name":"Tetrahedron chem","volume":"15 ","pages":"Article 100144"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Three-component redox-neutral alkene difunctionalization by radical copper catalysis\",\"authors\":\"Zhiming Feng , Jincai Zheng , Wei Zhou , Cong-Ying Zhou , Chengming Wang\",\"doi\":\"10.1016/j.tchem.2025.100144\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Three-component olefin difunctionalization represents a powerful strategy for constructing complex organic molecules. However, its advancement has been constrained by persistent challenges in chemoselectivity, environmental sustainability, and cost efficiency. The synergistic integration of cost-effective copper catalysis with radical chemistry offers a promising approach to address these limitations. This review provides a comprehensive analysis of copper-catalyzed, redox-neutral three-component olefin difunctionalization reactions, systematically examining both the diverse reaction types and their underlying mechanisms.</div></div>\",\"PeriodicalId\":74918,\"journal\":{\"name\":\"Tetrahedron chem\",\"volume\":\"15 \",\"pages\":\"Article 100144\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron chem\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666951X25000269\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron chem","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666951X25000269","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Three-component redox-neutral alkene difunctionalization by radical copper catalysis
Three-component olefin difunctionalization represents a powerful strategy for constructing complex organic molecules. However, its advancement has been constrained by persistent challenges in chemoselectivity, environmental sustainability, and cost efficiency. The synergistic integration of cost-effective copper catalysis with radical chemistry offers a promising approach to address these limitations. This review provides a comprehensive analysis of copper-catalyzed, redox-neutral three-component olefin difunctionalization reactions, systematically examining both the diverse reaction types and their underlying mechanisms.
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