长链非编码RNA MEG3 rs7158663多态性与脓毒症的发展易感性有关，并与脓毒症诱导的炎症反应有关

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-08-29 DOI:10.1016/j.cyto.2025.157019

Xiemuziya Maimaitirexiati , Minxin Wang , Huijing Zhao

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引用次数: 0

摘要

长链非编码RNA （lncRNA）的多态性可以影响患者对某些疾病的易感性。目的比较脓毒症患者和对照组中lncRNA MEG3 rs7158663多态性的基因型分布。进一步阐述了rs7158663与预后及患者炎症反应的关系。材料与方法选取350例脓毒症患者和320例对照组，对rs7158663位点进行基因分型，测定血清MEG3水平。通过构建K-M曲线来评价基因型与预后的关系。采用ELISA法检测血清炎症因子水平。结果rs7158663 GG基因型在脓毒症患者中的发生率高于对照组，而GA和AA基因型在脓毒症患者中的发生率低于对照组。MEG3 rs7158663 GA和AA基因型是脓毒症的非易感基因型，在优势模型中也观察到类似的遗传关联。分层分析显示，rs7158663与脓毒症的遗传相关性在不吸烟、不饮酒、年龄较大、BMI较低的人群中更为显著。MEG3 rs7158663 GG基因型携带者脓毒症患者MEG3升高，炎症因子释放过多，预后较差。结论meg3 rs7158663 GG基因型可能是脓毒症的易感基因型，与患者预后不良相关。可能与rs7158663介导的MEG3表达升高、炎性细胞因子过度释放有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Long non-coding RNA MEG3 rs7158663 polymorphism confers susceptibility to the development of sepsis and is associated with sepsis-induced inflammatory responses

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Long non-coding RNA MEG3 rs7158663 polymorphism confers susceptibility to the development of sepsis and is associated with sepsis-induced inflammatory responses

Background

The polymorphism of long non-coding RNA (lncRNA) can influence the susceptibility of patients to certain diseases.

Objectives

This study compared the genotype distribution of lncRNA MEG3 rs7158663 polymorphism in sepsis patients and controls. Furthermore, it elaborated on the relationship between rs7158663 and prognosis as well as the inflammatory response of the patients.

Materials and methods

350 sepsis patients and 320 controls were incorporated to conduct genotyping of the rs7158663 locus and to measure the serum MEG3 levels. The connection between genotypes and prognosis was appraised via the construction of K-M curves. The levels of serum inflammatory factors were measured with ELISA.

Results

Rs7158663 GG genotype occurred more frequently in sepsis patients than the control group, whereas the frequencies of the GA and AA genotypes were lower in the former. MEG3 rs7158663 GA and AA genotypes were non-susceptible genotypes for sepsis, and a similar genetic association was observed in the dominant model. Stratified analysis indicated that the genetic association between rs7158663 and sepsis was more significant in cases with non-smoking, non-drinking, older age, and low BMI. MEG3 rs7158663 GG genotype carriers had increased MEG3, excessive release of inflammatory factors, and poor prognosis in patients with sepsis.

Conclusion

MEG3 rs7158663 GG genotype may be a susceptibility genotype for sepsis and is associated with patients' poor prognosis. It might be related to rs7158663-mediated increase of MEG3 expression and excessive release of inflammatory cytokines.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.