{"title":"被挤压的细胞如何记住它们的形状,从而有效地迁移","authors":"","doi":"10.1038/s41567-025-02984-9","DOIUrl":null,"url":null,"abstract":"Cells migrating through narrow spaces in their environment undergo repeated shape changes to pass through tight constrictions. Epithelial cells retain a memory of past confinement, allowing them to maintain a polarized, compact morphology that enhances future migration through narrow gaps. This memory is mechanically encoded in the actin cortex.","PeriodicalId":19100,"journal":{"name":"Nature Physics","volume":"21 9","pages":"1359-1360"},"PeriodicalIF":18.4000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"How squeezed cells remember their shape to migrate efficiently\",\"authors\":\"\",\"doi\":\"10.1038/s41567-025-02984-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cells migrating through narrow spaces in their environment undergo repeated shape changes to pass through tight constrictions. Epithelial cells retain a memory of past confinement, allowing them to maintain a polarized, compact morphology that enhances future migration through narrow gaps. This memory is mechanically encoded in the actin cortex.\",\"PeriodicalId\":19100,\"journal\":{\"name\":\"Nature Physics\",\"volume\":\"21 9\",\"pages\":\"1359-1360\"},\"PeriodicalIF\":18.4000,\"publicationDate\":\"2025-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Physics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://www.nature.com/articles/s41567-025-02984-9\",\"RegionNum\":1,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Physics","FirstCategoryId":"101","ListUrlMain":"https://www.nature.com/articles/s41567-025-02984-9","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
How squeezed cells remember their shape to migrate efficiently
Cells migrating through narrow spaces in their environment undergo repeated shape changes to pass through tight constrictions. Epithelial cells retain a memory of past confinement, allowing them to maintain a polarized, compact morphology that enhances future migration through narrow gaps. This memory is mechanically encoded in the actin cortex.
期刊介绍:
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