支气管肺发育不良细胞模型的建立与评价：挑战与展望

IF 2.3 4区医学 Q3 RESPIRATORY SYSTEM

Clinical Respiratory Journal Pub Date : 2025-08-27 DOI:10.1111/crj.70118

Zhenzhuang Zou, Li Fu, Jiaying Liu, Bo Huang

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引用次数: 0

摘要

支气管肺发育不良（BPD）是一种主要影响早产儿的慢性肺部疾病。这对他们的成长、发育和健康有很大的影响。最近，体外模型已经建立，为BPD的病因和潜在治疗提供了新的见解。本文综述了目前制备BPD体外模型的方法。并讨论了它们的评价标准及其在药物试验和生物学研究中的应用。本文评价了不同模型的优缺点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Establishment and Evaluation of Cell Models for Bronchopulmonary Dysplasia: Challenges and Prospects

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Establishment and Evaluation of Cell Models for Bronchopulmonary Dysplasia: Challenges and Prospects

Bronchopulmonary dysplasia (BPD) is a chronic lung condition primarily affecting premature infants. It significantly impacts their growth, development, and health. Recently, in vitro models have been created, offering new insights into the causes and potential treatments for BPD. This review summarizes the current methods for creating in vitro models of BPD. It also discusses their evaluation criteria and applications in drug testing and biological research. This paper evaluates the advantages and disadvantages of different models.

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来源期刊

Clinical Respiratory Journal 医学-呼吸系统

CiteScore

3.70

自引率

0.00%

发文量

104

审稿时长

>12 weeks

期刊介绍： Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)