Luciana Cicco, Arfa Yousaf, Paola Vitale, Filippo Maria Perna and Vito Capriati
{"title":"里特反应的可持续转变:铁基深共晶溶剂作为酰胺合成的绿色途径","authors":"Luciana Cicco, Arfa Yousaf, Paola Vitale, Filippo Maria Perna and Vito Capriati","doi":"10.1039/D5SU00489F","DOIUrl":null,"url":null,"abstract":"<p >A sustainable and scalable Ritter reaction protocol has been developed for the efficient amidation of diverse secondary and tertiary alcohols with both aliphatic and aromatic nitriles, employing a reusable FeCl<small><sub>3</sub></small>·6H<small><sub>2</sub></small>O/glycerol Lewis acidic deep eutectic solvent. The method features mild, aerobic conditions and broad substrate scope, and delivers yields of up to 98% without chromatographic purification. CHEM21 green metrics underscore the significantly reduced environmental footprint of this approach, establishing it as a greener and more efficient alternative to conventional amide synthesis protocols. The practical utility of the method is further demonstrated by the gram-scale synthesis of drug Chlodantane, showcasing its potential for sustainable applications in pharmaceutical manufacturing.</p>","PeriodicalId":74745,"journal":{"name":"RSC sustainability","volume":" 9","pages":" 4079-4086"},"PeriodicalIF":4.9000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/su/d5su00489f?page=search","citationCount":"0","resultStr":"{\"title\":\"A sustainable twist on the Ritter reaction: iron-based deep eutectic solvents as a green route to amide synthesis†\",\"authors\":\"Luciana Cicco, Arfa Yousaf, Paola Vitale, Filippo Maria Perna and Vito Capriati\",\"doi\":\"10.1039/D5SU00489F\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >A sustainable and scalable Ritter reaction protocol has been developed for the efficient amidation of diverse secondary and tertiary alcohols with both aliphatic and aromatic nitriles, employing a reusable FeCl<small><sub>3</sub></small>·6H<small><sub>2</sub></small>O/glycerol Lewis acidic deep eutectic solvent. The method features mild, aerobic conditions and broad substrate scope, and delivers yields of up to 98% without chromatographic purification. CHEM21 green metrics underscore the significantly reduced environmental footprint of this approach, establishing it as a greener and more efficient alternative to conventional amide synthesis protocols. The practical utility of the method is further demonstrated by the gram-scale synthesis of drug Chlodantane, showcasing its potential for sustainable applications in pharmaceutical manufacturing.</p>\",\"PeriodicalId\":74745,\"journal\":{\"name\":\"RSC sustainability\",\"volume\":\" 9\",\"pages\":\" 4079-4086\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://pubs.rsc.org/en/content/articlepdf/2025/su/d5su00489f?page=search\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"RSC sustainability\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/su/d5su00489f\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC sustainability","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/su/d5su00489f","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A sustainable twist on the Ritter reaction: iron-based deep eutectic solvents as a green route to amide synthesis†
A sustainable and scalable Ritter reaction protocol has been developed for the efficient amidation of diverse secondary and tertiary alcohols with both aliphatic and aromatic nitriles, employing a reusable FeCl3·6H2O/glycerol Lewis acidic deep eutectic solvent. The method features mild, aerobic conditions and broad substrate scope, and delivers yields of up to 98% without chromatographic purification. CHEM21 green metrics underscore the significantly reduced environmental footprint of this approach, establishing it as a greener and more efficient alternative to conventional amide synthesis protocols. The practical utility of the method is further demonstrated by the gram-scale synthesis of drug Chlodantane, showcasing its potential for sustainable applications in pharmaceutical manufacturing.