How do you (dis)solve a problem like methylene chloride?†

Chemical regulation in the European Union (EU) and the United States of America (USA) has restricted the use of some historically important solvents, essentially banning certain uses. The most high profile regulatory action thus far has been a ‘Final Risk Management Rule’ prohibiting all consumer uses, and many commercial uses, of methylene chloride (dichloromethane, DCM) by the United States Environmental Protection Agency (EPA) through the Toxic Substances Control Act (TSCA). The unique properties of chlorinated solvents makes direct substitution difficult or impossible for most uses, and creative solutions are needed. The replacement of methylene chloride in synthesis, extraction, and chromatography with green solvents will be discussed as a way of using regulatory intervention as the catalyst for innovation and positive change.