生长激素缺乏儿童1年生长激素替代治疗前后血清富亮氨酸α-2糖蛋白1 （LRG1）、前神经紧张素（PNT）、脂肪酸结合蛋白4 （FABP4）和furin水平的变化

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-08-28 DOI:10.1016/j.cyto.2025.157022

Zhibo Zhou , Yuxin Sun , Zeyan Zheng , Xiaoyuan Guo , Hongbo Yang , Shi Chen , Hui Pan , Huijuan Zhu

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引用次数: 0

摘要

目的探讨生长激素缺乏症（GHD）患儿血清富白氨酸α-2糖蛋白1 （LRG1）、前神经紧张素（PNT）、脂肪酸结合蛋白4 （FABP4）、furin水平与特发性身材矮小（ISS）及健康儿童的比较，并评价其在1年生长激素替代治疗（GHRT）后的变化及其临床意义。方法对32例特发性GHD、32例ISS和32例健康儿童进行前瞻性队列研究。在基线及GHRT治疗6个月和12个月后测定血清LRG1、PNT、FABP4、furin及临床参数。相关分析用于评估这些脂肪因子与临床变量之间的关联。使用限制性三次样条曲线和多变量logistic回归来评估脂肪因子与GHD风险之间的关系。结果与ISS和健康对照组相比，GHD儿童的sat基线、PNT和furin水平显著升高，而LRG1水平较低。ght治疗1年后，GHD患者的LRG1、PNT、FABP4和furin水平显著降低。男性和GHD患者PNT水平较高，FABP4水平与GVSDS、BMISDS呈正相关，与FBG呈负相关。较高的PNT水平与GHD风险增加相关（OR = 15.545, P < 0.001），而较高的LRG1水平与GHD风险降低相关（OR = 0.291, P = 0.034）。结论hd患儿PNT、furin水平较高，LRG1水平较低。在GHRT期间，LRG1、PNT、FABP4和furin水平显著下降，提示GHRT具有良好的代谢作用和潜在的长期益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Serum levels of leucine-rich α–2 glycoprotein 1 (LRG1), pro-neurotensin (PNT), fatty acid-binding protein 4 (FABP4) and furin in pediatric growth hormone deficiency before and after 1-year growth hormone replacement therapy

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Objective

To investigate serum levels of leucine-rich α–2 glycoprotein 1 (LRG1), pro-neurotensin (PNT), fatty acid-binding protein 4 (FABP4), and furin in children with growth hormone deficiency (GHD) compared to idiopathic short stature (ISS) and healthy children, and to evaluate their changes and clinical relevance after 1-year growth hormone replacement therapy (GHRT).

Methods

The prospective cohort study was conducted in 32 idiopathic GHD, 32 ISS and 32 healthy children. Serum LRG1, PNT, FABP4, furin and clinical parameters were measured at baseline and after 6 and 12 months of GHRT. Correlation analyses were used to assess the associations between these adipokines and clinical variables. Restricted cubic spline curves and multivariable logistic regressions were used to assess the relationships between adipokines and GHD risk.

Results

At baseline, PNT and furin levels were significantly higher, while LRG1 was lower in GHD children compared to ISS and healthy controls. After 1-year GHRT, LRG1, PNT, FABP4, and furin levels significantly decreased in GHD patients. PNT levels were higher in male and GHD patients, and FABP4 levels were positively related with GV_SDS, BMI_SDS and negatively with FBG. Higher PNT levels were associated with increased GHD risks (OR = 15.545, P < 0.001), while and higher LRG1 levels were associated with decreased GHD risks (OR = 0.291, P = 0.034).

Conclusion

GHD children have higher PNT and furin levels and lower LRG1 levels. During GHRT, LRG1, PNT, FABP4 and furin levels significantly decline, suggesting favorable metabolic effects and potential long-term benefits of GHRT.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.