核因子红系衍生2样1在癌症中的作用机制及治疗作用

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-08-24 DOI:10.1016/j.cellsig.2025.112083

Xuye Zhao , Chenxi Zhan , Yi Ding , Li Yu , Nianlong Yan

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引用次数: 0

摘要

核因子，红系衍生2 -样1 （NFE2L1）是CNC-bZIP转录因子家族的成员，通过影响氧化应激、蛋白酶体活性等因素，是细胞内稳态的关键调节因子。NFE2L1在肿瘤发生和进展中起双重作用；这些过程背后的分子机制被部分理解，并与氧化应激、蛋白酶体活性和代谢途径密切相关。此外，NFE2L1还通过主要调节抗氧化作用和蛋白酶体活性在癌症治疗中发挥作用。因此，本综述综合了NFE2L1在癌症中的机制和治疗作用的现有证据，并强调了指导未来研究的关键未解决问题。

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The mechanisms and therapeutic role of nuclear factor, erythroid derived 2,-like 1 in cancers

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The mechanisms and therapeutic role of nuclear factor, erythroid derived 2,-like 1 in cancers

Nuclear factor, erythroid derived 2,-like 1 (NFE2L1), a member of the CNC-bZIP transcription factor family, is a key regulator of cellular homeostasis by influencing oxidative stress, proteasome activity, and other factors. NFE2L1 plays a dual role in tumor development and progression; the molecular mechanisms underlying these processes are partially understood and are closely associated with oxidative stress, proteasome activity, and metabolic pathways. Furthermore, NFE2L1 also plays a role in cancer therapy by primarily regulating antioxidant effects and proteasome activity. Therefore, this review synthesizes current evidence of the mechanisms and therapeutic role of NFE2L1 in cancers, and highlights critical unresolved questions to guide future research.

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.