女性唇裂和/或腭裂患者颅面生长模式：从婴儿期到青春期的纵向研究

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-05-06 DOI:10.1016/j.ajoms.2025.05.004

Akira Suzuki , Naoko Tamura , Masaaki Sasaguri , Takeshi Mitsuyasu , Seiji Nakamura

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引用次数: 0

摘要

目的：唇腭裂患者颅面形态异常主要是由于颅面生长潜能缺陷以及手术和正畸治疗的影响。通过分析从婴儿期到成年期整个生长过程中颅面生长模式来检查这些因素的影响。设计回顾性纵向研究参与者：研究对象为46名在日本福冈九州大学牙科医院接受唇部和/或腭部手术修复和正畸治疗的日本女性CL/P患者。方法使用4个月至15 + 岁的连续头颅x线片，采用重复测量方差分析比较3种唇裂类型（12例UCLA、13例CP和21例UCLP）的颅面形态生长模式。结果UCLP患者与UCLA患者在颌面角（S-N-A）、上颌基底长度（A′-Ptm′）、后上颌高度（S-Ptm′）、颌面宽度（NC-NC′和Mx-Mx′）以及三种颌面比例（Cd-Go/S-N、Pog-Go/S-N、N-PP/Cd-Go）的生长模式上存在差异。UCLP患者与CP患者在颅底长度（N-Ba和S-Ba）、上颌基底长度、颌面角、颌面宽度、S-Ptm′/N-PP比值等方面的生长模式存在差异。结论唇腭裂患者颅面生长模式随腭裂类型的不同而不同，唇腭裂同时存在会抑制后颌面复合体的向前和向下生长，唇部、牙槽骨和腭部的手术干预对颌面生长具有累积抑制作用。

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Craniofacial growth patterns of female patients with cleft lip and/or palate: A longitudinal study from infancy to adolescence

Objectives

Abnormal craniofacial morphology in patients with cleft lip and/or palate has been attributed to defects in craniofacial growth potential and to the effects of surgical and orthodontic treatment. The influence of these factors was examined by analyzing craniofacial growth patterns throughout the growth process from infancy to adulthood.

Design

Retrospective longitudinal study

Participants

The subjects were 46 Japanese female CL/P patients who underwent surgical lip and/or palatal repairs and orthodontic treatment at the Kyushu University Dental Hospital, Fukuoka, Japan.

Methods

Using serial cephalometric radiographs from 4 months to 15 + years of age, growth patterns of craniofacial morphology were compared for three cleft types (12 patients with UCLA, 13 CP, and 21 UCLP) using repeated measures ANOVA.

Results

The growth patterns of the patients with UCLP differed from those of the patients with UCLA in the maxillofacial angle (S-N-A), maxillary basal length (A’-Ptm’), posterior maxillary height (S-Ptm’), maxillofacial widths (NC-NC’ and Mx-Mx’), and three maxillofacial ratios (Cd-Go/S-N, Pog-Go/S-N, N-PP/Cd-Go). The growth patterns of the patients with UCLP differed from those of the patients with CP in cranial base lengths (N-Ba and S-Ba), the maxillary basal length, maxillofacial angle, maxillofacial width, and the ratio S-Ptm'/N-PP.

Conclusion

Craniofacial growth patterns varied by the cleft types, the presence of both cleft lip and cleft palate inhibited forward and downward growth of the posterior maxillofacial complex, and surgical intervention on the lips, alveolar bone, and palate had a cumulative inhibitory effect on maxillofacial growth.

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