训练免疫及其在化脓性汗腺炎发病机制中的潜在意义:慢性炎症的新范式?

IF 3.1 3区 医学 Q1 DERMATOLOGY
Annalisa Marcuzzi, Erika Rimondi, Giada Lodi, Marta Manfredini, Paola Maura Tricarico, Chiara Moltrasio, Angelo Valerio Marzano, Muhammad Suleman, Paola Secchiero, Elisabetta Melloni, Sergio Crovella
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引用次数: 0

摘要

化脓性汗腺炎(HS)是一种慢性自身炎症性皮肤病,其特征是反复出现疼痛的结节、脓肿和隧道,通常导致组织破坏,严重影响生活质量。尽管对HS的认识有了进步,但HS仍然是一种复杂的疾病,其确切的发病机制尚未揭示。然而,先天免疫反应失调的作用已经确定,可能导致持续和慢性炎症。最近免疫学的进展强调了训练免疫的概念,这是一种先天免疫记忆的形式,可能为HS病理生理学提供新的见解。训练免疫是由先天免疫细胞的表观遗传和代谢重编程介导的,即使在没有原始触发因素的情况下,它们也能在随后的刺激下产生更高和更长时间的炎症反应。我们假设训练免疫可能有助于持续炎症状态,影响HS的进展和严重程度。环境和微生物因素可能作为持续刺激,导致先天免疫途径的激活。从机制的角度来看,HS的免疫训练可能涉及细胞因子产生增加,髓细胞分化改变和持续的表观遗传修饰,有利于促炎表型。识别与HS中训练免疫相关的特定分子标记可以提供新的诊断和预后工具,并可能开辟新的治疗途径。通过探索训练免疫在HS中的潜在作用,我们为慢性炎症提供了一个新的视角,从而假设了参与这种复杂疾病的病因/发病机制的另一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Trained Immunity and Its Potential Implications in the Etiopathogenesis of Hidradenitis Suppurativa: A New Paradigm in Chronic Inflammation?

Trained Immunity and Its Potential Implications in the Etiopathogenesis of Hidradenitis Suppurativa: A New Paradigm in Chronic Inflammation?

Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disorder characterised by recurrent, painful nodules, abscesses and tunnels, often leading to tissue destruction with a significant impairment in quality of life. Despite advancements in understanding, HS remains a complex disease, whose exact pathogenesis is yet to be revealed. Nevertheless, the role of a dysregulated innate immune response has been established, potentially contributing to the persistent and chronic inflammation. Recent advances in immunology have highlighted the concept of trained immunity, a form of innate immune memory that may provide new insights into HS pathophysiology. Trained immunity is mediated by epigenetic and metabolic reprogramming of innate immune cells, enabling them to mount a heightened and prolonged inflammatory response upon subsequent stimuli, even in the absence of the original trigger. We hypothesize that trained immunity could contribute to the persistent inflammatory state, influencing HS progression and severity. Environmental and microbial factors may act as persistent stimuli, leading to activation of innate immune pathways. From a mechanistic perspective, trained immunity in HS might involve increased cytokine production, altered myeloid cell differentiation and persistent epigenetic modifications favouring a pro-inflammatory phenotype. Identifying specific molecular markers associated with trained immunity in HS could provide new diagnostic and prognostic tools and may open novel therapeutic avenues. By exploring the potential role of trained immunity in HS, we provide a new perspective on chronic inflammation, thus hypothesizing another actor involved in the aetiology/pathogenesis of this complex disease.

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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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