临床,皮肤镜和反射共聚焦显微镜特征与Spitzoid肿瘤中阴性色素网络的存在相关

IF 3.1 3区 医学 Q1 DERMATOLOGY
Marco Spadafora, Francesca Farnetani, Stefania Borsari, Shaniko Kaleci, Dafi Porat, Silvana Ciardo, Ignazio Stanganelli, Caterina Longo, Giovanni Pellacani, Alon Scope
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引用次数: 0

摘要

负性色素网络(NPN)是一种皮肤镜结构,常与黑色素瘤相关。虽然通常在Spitz naevi (SN)和Spitzoid melanoma (SM)中观察到,但其反射共聚焦显微镜(RCM)相关性主要在非Spitzoid黑色素细胞肿瘤中研究。本研究旨在确定皮镜下Spitzoid肿瘤NPN的临床、皮肤镜和RCM特征,并探讨其组织病理学相关性。我们回顾性分析了2014年至2020年间诊断的128例组织病理学证实的SN和SM病例的临床、皮肤镜和RCM图像。根据皮镜下有无NPN对病变进行分组,并对临床、皮镜下和RCM特征进行比较。20例进行了组织病理学相关性分析。128例中,SN 96例(74%),SM 32例(26%)。NPN存在于58个病变(45%)-40个SN(42%)和18个SM(56%)。NPN与病变直径≥5mm、存在亮白色结构、星点状血管相关,弥漫性蓝白色膜呈负相关。SMs显示出更高的不对称频率、多分量模式和广泛的NPN。以前与NPN相关的RCM特征-圆形或线状表面破坏,基底上区域明亮,乳头间隙变宽-在87%的病例中可见,但与诊断或皮肤镜下NPN无关。相应的组织学特征包括角蛋白填充的谷,颗粒增多,网状隆起或漏斗变宽。皮镜下NPN的RCM相关性在Spitzoid肿瘤中经常观察到,独立于可见的皮镜下NPN,提示可感知性可能取决于皮镜模式内的对比。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinical, Dermoscopic and Reflectance Confocal Microscopy Characteristics Associated With the Presence of Negative Pigment Network Among Spitzoid Neoplasms

Clinical, Dermoscopic and Reflectance Confocal Microscopy Characteristics Associated With the Presence of Negative Pigment Network Among Spitzoid Neoplasms

Negative pigment network (NPN) is a dermoscopic structure frequently associated with melanoma. Though commonly observed in Spitz naevi (SN) and Spitzoid melanoma (SM), its reflectance confocal microscopy (RCM) correlates have been primarily studied in non-Spitzoid melanocytic neoplasms. This study aimed to identify clinical, dermoscopic, and RCM features associated with dermoscopic NPN in Spitzoid neoplasms and explore its histopathological correlates. We retrospectively analysed clinical, dermoscopic, and RCM images from 128 histopathologically confirmed SN and SM cases diagnosed between 2014 and 2020. Lesions were grouped by presence or absence of dermoscopic NPN, and comparisons were made across clinical, dermoscopic, and RCM features. A subset of 20 cases underwent histopathologic correlation. Of the 128 cases, 96 (74%) were SN and 32 (26%) SM. NPN was present in 58 lesions (45%)—40 SN (42%) and 18 SM (56%). NPN was associated with lesion diameter ≥ 5 mm, presence of shiny white structures, dotted vessels, and inversely associated with diffuse blue-white veil. SMs showed higher frequencies of asymmetry, multicomponent patterns, and extensive NPN. RCM features previously linked to NPN—round or linear surface disruptions, bright suprabasal areas, and broadened interpapillary spaces—were seen in 87% of cases but did not correlate with diagnosis or dermoscopic NPN. Corresponding histologic features included keratin-filled dells, hypergranulosis, and broadened rete ridges or infundibula. RCM correlates of dermoscopic NPN are frequently observed in Spitzoid neoplasms, independent of visible dermoscopic NPN, suggesting perceptibility may depend on contrast within dermoscopic patterns.

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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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