Fangxia Zhao, Xunnan Wan, Yan Liang, Weidong Liu, Jianqiang Liu, Ying Pan, Alireza Nezamzadeh-Ejhieh, Xiaoxiu Li
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Prospects, Advances, and Applications of BioMOF-Based Platforms
Bio-metal-organic frameworks (bio-MOFs) have emerged as a revolutionary group of hybrid materials distinguished by their exceptional biocompatibility, programmable biodegradability, and host–guest molecular recognition capabilities. This review systematically examines recent advancements in bio-MOF engineering, with particular focus on the innovative synthesis strategies and the structure–property relationships arising from their tunable pore architectures and surface functionalities. The mechanistic foundations of bio-MOFs in targeted drug delivery systems, contrast-enhanced bioimaging, and multifunctional therapeutic interventions combining anti-inflammatory and antibacterial actions are discussed in detail. Finally, in terms of future perspectives, we discuss emerging opportunities in other delivery systems, personalized medicine platforms, and sustainable environmental applications, underscoring the necessity for cross-disciplinary collaboration between materials science and molecular biology to unlock the full potential of these biohybrid systems.
期刊介绍：
Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science.
Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community.
In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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