微弧氧化/聚乳酸-羟基乙酸复合涂层对ZK60镁合金降解及生物相容性的影响

IF 7.3 2区材料科学 Q1 CHEMISTRY, APPLIED

Progress in Organic Coatings Pub Date : 2025-08-27 DOI:10.1016/j.porgcoat.2025.109619

Xueying Zhang , Jing Wang , Huancai Li , Bo Zhu , Huijun Yu , Chuanzhong Chen

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引用次数: 0

摘要

在ZK60镁合金表面设计了微弧氧化（MAO）陶瓷层和聚乳酸-羟基乙酸（PLGA）复合涂层，以实现协同防腐和生物集成。通过改变乳酸/乙醇酸（LA/GA）共聚比，研究了涂层的微观结构、组成、电化学、体外降解和生物相容性的演变，建立了涂层的组成-结构-性能关系。复合涂层的双层结构提供双重保护：MAO层通过提供离子缓冲和防止Cl−扩散提供物理屏障保护。同时，PLGA层通过粘性流动密封MAO陶瓷层中的缺陷，并通过疏水效应降低SBF穿透。电化学分析表明，物理屏障和化学钝化作用相结合的协同策略使MAO/PLGA8515复合涂层具有最佳的耐蚀性，其防护效率为99.66±0.06%。此外，PLGA聚合物水解释放的乳酸衍生物稳定了pH，为细胞增殖和粘附提供了合适的微环境。同时，PLGA使与复合涂层共培养的成骨细胞呈现出细长的丝状突起和纺锤状形态，细胞存活率高于95%，具有良好的细胞相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Effects of micro-arc oxidation/poly(lactic-co-glycolic acid) composite coating on the degradation and biocompatibility of ZK60 magnesium alloy

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Effects of micro-arc oxidation/poly(lactic-co-glycolic acid) composite coating on the degradation and biocompatibility of ZK60 magnesium alloy

The composite coating consisting of a micro-arc oxidation (MAO) ceramic layer and a poly(lactic-co-glycolic acid) (PLGA) layer was designed on ZK60 magnesium alloy for synergistic corrosion protection and bio-integration. The evolution of microstructure, composition, electrochemistry, in vitro degradation, and biocompatibility of the coatings was investigated by varying the lactic acid/glycolic acid (LA/GA) copolymerization ratio, and the composition-structure-property relationship was established. The bilayer structure of the composite coating provides dual protection: the MAO layer provides physical barrier protection by providing ionic buffer and preventing Cl⁻ diffusion. At the same time, the PLGA layer seals the defects in the MAO ceramic layer through viscous flow and reduces the SBF penetration through the hydrophobic effect. Electrochemical analysis shows that the synergistic strategy of combining physical barrier and chemical passivation effects endows optimal corrosion resistance to the MAO/PLGA8515 composite coating with a protection efficiency of 99.66 ± 0.06 %. In addition, the lactic acid derivatives released from the hydrolysis of PLGA polymer stabilize the pH, providing a suitable microenvironment for cell proliferation and adhesion. Meanwhile, the PLGA enables the osteoblasts co-cultured with the composite coating to exhibit elongated filopodia protrusions and spindle-like morphology and higher than 95 % cell viability, showing superior cytocompatibility.

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来源期刊

Progress in Organic Coatings 工程技术-材料科学：膜

CiteScore

11.40

自引率

15.20%

发文量

577

审稿时长

48 days

期刊介绍： The aim of this international journal is to analyse and publicise the progress and current state of knowledge in the field of organic coatings and related materials. The Editors and the Editorial Board members will solicit both review and research papers from academic and industrial scientists who are actively engaged in research and development or, in the case of review papers, have extensive experience in the subject to be reviewed. Unsolicited manuscripts will be accepted if they meet the journal''s requirements. The journal publishes papers dealing with such subjects as: • Chemical, physical and technological properties of organic coatings and related materials • Problems and methods of preparation, manufacture and application of these materials • Performance, testing and analysis.