对短期饮食交叉试验有效性的担忧

IF 50 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Medicine Pub Date : 2025-08-22 DOI:10.1038/s41591-025-03909-y

David S. Ludwig, Walter C. Willett, Mary E. Putt

引用次数: 0

摘要

源自k.d. Hall等人。Nature Medicine https://doi.org/10.1038/s41591-020-01209-1（2021）膳食成分如何影响新陈代谢和体重？解决这一问题的可靠实验数据将对肥胖发病机制的研究和设计更有效的预防和治疗具有重要意义。根据被称为被动过度消费或能量平衡模型的传统观点，高脂肪、高能量密度、超美味的食物会导致暴饮暴食和体重增加。在碳水化合物-胰岛素模型（CIM）1,2,3中，快速消化（即高血糖负荷）和高糖碳水化合物会导致脂肪沉积，从而导致暴饮暴食。因此，这两个模型持有相反的因果方向的观点。为了区分它们，Hall等人4进行了一项两处理、两期（2 × 2）交叉喂养研究，其中饮食组为2周。他们报告说，低碳水化合物生酮饮食（LC）比低脂饮食（LF）每天的自由能量摄入多689千卡，这一发现被解释为与CIM的预测不一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Concern for the validity of short-term dietary crossover trials

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Concern for the validity of short-term dietary crossover trials

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来源期刊

Nature Medicine 医学-生化与分子生物学

CiteScore

100.90

自引率

0.70%

发文量

525

审稿时长

1 months

期刊介绍： Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors. Nature Medicine consider all types of clinical research, including: -Case-reports and small case series -Clinical trials, whether phase 1, 2, 3 or 4 -Observational studies -Meta-analyses -Biomarker studies -Public and global health studies Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.