双Au(I)催化双[1.1.0]丁烷与烯的区域选择性环加成反应

IF 13.1 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2025-08-26 DOI:10.1021/acscatal.5c03898

Riccardo Giovanelli, Giulio Gallorini, Yuhao Huang, Andrea Brunetti, Kyriakos D. Nikopoulos, Magda Monari, Carlos Silva López, Sofia Kiriakidi*, Giulio Bertuzzi* and Marco Bandini*,

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引用次数: 0

摘要

报道了富电子烯和双环丁烷（BCBs）在金催化下的[2π+2σ]形式环加成反应。通过动力学研究和详细的DFT分析，揭示了双金活化机制，为均相金催化双活化策略引入了有趣的范式。该方案能够以高收率（高达93%）合成广泛的密集功能化双环己烷（32个例子），具有完全的区域选择性和立体选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Dual Au(I) Catalysis in Regioselective Cycloaddition of Bicyclo[1.1.0]butanes with Allenes

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Dual Au(I) Catalysis in Regioselective Cycloaddition of Bicyclo[1.1.0]butanes with Allenes

A formal [2π+2σ] cycloaddition between electron-rich allenes and bicyclobutanes (BCBs), under a gold-catalyzed regime, is reported. A dual gold activation mechanism was revealed through kinetic studies and further supported by detailed DFT analysis, introducing intriguing paradigms into the dual activation strategy of homogeneous Au catalysis. This protocol enables the synthesis of a broad array of densely functionalized bicyclohexanes (32 examples) in high yields (up to 93%) with complete regioselectivity and stereoselectivity.

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.