内质网中多伴侣凝聚物的发现

IF 19.1 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-08-20 DOI:10.1038/s41556-025-01731-9

引用次数: 0

摘要

如何组织多个伴侣来协调他们的活动尚不清楚。我们观察到伴侣PDIA6在内质网中形成相分离凝聚体，其中招募了几个额外的伴侣。这些多伴侣蛋白凝聚体构成了一个专用的内质网亚室，促进蛋白质的生物生成，防止蛋白质错误折叠和聚集。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Discovery of a multi-chaperone condensate in the endoplasmic reticulum

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Discovery of a multi-chaperone condensate in the endoplasmic reticulum

How multiple chaperones are organized to co-ordinate their activities has been unclear. We observed that the chaperone PDIA6 forms phase-separated condensates in the endoplasmic reticulum to which several additional chaperones are recruited. These multi-chaperone condensates constitute a dedicated endoplasmic reticulum sub-compartment that facilitates protein biogenesis and prevents protein misfolding and aggregation.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology