自身免疫性甲状腺功能减退患者牙周参数与甲状腺标志物之间的关系:一项横断面研究

IF 3.8 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Sunitha Puthiyapurayil, Rosamma Joseph Vadakkekuttical, Thulaseedharan Nallaveettil Kesavan, Harikumar Kanakkath
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This study was undertaken to assess the prevalence and severity of periodontitis, to correlate clinical attachment loss (CAL), and periodontal inflamed surface area (PISA) with anti‐thyroid peroxidase (anti‐TPO) antibody, triiodothyronine (T3), thyroxine (T4), thyroid‐ stimulating hormone (TSH), and C‐reactive protein (CRP) in autoimmune hypothyroid patients and systemically healthy subjects.MethodsThis cross‐sectional study comprised of 65 autoimmune hypothyroid patients under treatment and 75 systemically healthy subjects. All participants were evaluated for periodontal parameters (bleeding on probing (BoP), probing pocket depth (PPD), CAL, oral hygiene index‐simplified (OHI‐S Index), Plaque Index (PI) and PISA) and systemic parameters (T3, T4, TSH, anti‐TPO antibody, and CRP). Analysis of quantitative and qualitative data was done by unpaired <jats:italic>t</jats:italic>‐test and Chi‐Square test, respectively.ResultsPrevalence and severity of periodontitis in the autoimmune hypothyroid group were significantly higher compared with the systemically healthy group (<jats:italic>p</jats:italic> &lt; 0.001). CAL, PISA, T3, TSH, and anti‐TPO antibody were significantly higher in the autoimmune hypothyroid group as compared with the systemically healthy group. Mean CAL and PISA were positively correlated with anti‐TPO antibody, T3, T4, TSH, and CRP. The multivariate linear regression model with dependent variable mean CAL showed that anti‐TPO antibody was significantly associated with mean CAL (<jats:italic>β</jats:italic> = 0.001, <jats:italic>p </jats:italic>= 0.02).ConclusionsAutoimmune hypothyroid subjects exhibited a higher prevalence and severity of periodontitis compared with the systemically healthy group. 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引用次数: 0

摘要

背景炎性细胞因子在自身免疫性甲状腺功能减退症和牙周病的发病机制中起重要作用。这些炎症标记物的累积效应可能导致广泛的牙周破坏。本研究旨在评估自身免疫性甲状腺功能减退患者和全身健康受试者中牙周炎的患病率和严重程度,并将临床附着丧失(CAL)和牙周炎症表面积(PISA)与抗甲状腺过氧化物酶(anti - TPO)抗体、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)和C反应蛋白(CRP)联系起来。方法本横断面研究包括65例自身免疫性甲状腺功能减退患者和75例全身健康受试者。对所有参与者进行牙周参数(探诊出血(BoP)、探诊袋深度(PPD)、CAL、口腔卫生指数简化(OHI - S指数)、斑块指数(PI)和PISA)和系统参数(T3、T4、TSH、抗TPO抗体和CRP)的评估。定量和定性数据分析分别采用非配对t检验和卡方检验。结果自身免疫性甲状腺功能减退组牙周炎的患病率和严重程度明显高于全身健康组(p < 0.001)。与系统健康组相比,自身免疫性甲状腺功能减退组的CAL、PISA、T3、TSH和抗TPO抗体显著升高。平均CAL和PISA与抗TPO抗体、T3、T4、TSH和CRP呈正相关。因变量平均CAL的多元线性回归模型显示,抗TPO抗体与平均CAL显著相关(β = 0.001, p = 0.02)。结论自身免疫性甲状腺功能减退患者牙周炎的患病率和严重程度均高于全身健康组。自身免疫性甲状腺功能减退组的BoP、PPD、CAL和PISA均高于全身健康组。CAL、PISA与抗TPO抗体、T3、TSH、CRP呈显著正相关。本研究通过比较65名自身免疫性甲状腺功能减退患者和75名健康受试者,评估自身免疫性甲状腺功能减退症(一种以甲状腺功能减退为特征的疾病)与牙周炎之间的联系。这项研究测量了牙周健康指标、甲状腺激素水平和炎症标志物。结果表明,自身免疫性甲状腺功能减退患者牙周疾病更严重,牙周组织损失增加。他们还表现出特定甲状腺抗体水平升高和甲状腺激素失衡。重要的是,牙周组织损失的程度与这些甲状腺相关标志物,特别是抗TPO抗体之间存在显著的正相关。综上所述,自身免疫性甲状腺功能减退症患者患严重牙周病的风险更高,提示甲状腺功能障碍与牙周健康之间存在关联。因此,对于牙周病医生和内分泌学家来说,在计划适当的治疗时认识到这种联系是至关重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between periodontal parameters and thyroid markers in autoimmune hypothyroidism: A cross‐sectional study
BackgroundInflammatory cytokines play a significant role in the pathogenesis of both autoimmune hypothyroidism and periodontal disease. The cumulative effect of these inflammatory markers may lead to extensive periodontal breakdown. This study was undertaken to assess the prevalence and severity of periodontitis, to correlate clinical attachment loss (CAL), and periodontal inflamed surface area (PISA) with anti‐thyroid peroxidase (anti‐TPO) antibody, triiodothyronine (T3), thyroxine (T4), thyroid‐ stimulating hormone (TSH), and C‐reactive protein (CRP) in autoimmune hypothyroid patients and systemically healthy subjects.MethodsThis cross‐sectional study comprised of 65 autoimmune hypothyroid patients under treatment and 75 systemically healthy subjects. All participants were evaluated for periodontal parameters (bleeding on probing (BoP), probing pocket depth (PPD), CAL, oral hygiene index‐simplified (OHI‐S Index), Plaque Index (PI) and PISA) and systemic parameters (T3, T4, TSH, anti‐TPO antibody, and CRP). Analysis of quantitative and qualitative data was done by unpaired t‐test and Chi‐Square test, respectively.ResultsPrevalence and severity of periodontitis in the autoimmune hypothyroid group were significantly higher compared with the systemically healthy group (p < 0.001). CAL, PISA, T3, TSH, and anti‐TPO antibody were significantly higher in the autoimmune hypothyroid group as compared with the systemically healthy group. Mean CAL and PISA were positively correlated with anti‐TPO antibody, T3, T4, TSH, and CRP. The multivariate linear regression model with dependent variable mean CAL showed that anti‐TPO antibody was significantly associated with mean CAL (β = 0.001, p = 0.02).ConclusionsAutoimmune hypothyroid subjects exhibited a higher prevalence and severity of periodontitis compared with the systemically healthy group. BoP, PPD, CAL and PISA were also higher in autoimmune hypothyroid group as compared with the systemically healthy group. A statistically significant positive correlation of CAL, and PISA with anti‐TPO antibody, T3, TSH, and CRP was observed.Plain language summaryThis study assessed the link between autoimmune hypothyroidism (a condition characterized by decreased thyroid function) and periodontitis by comparing 65 individuals with autoimmune hypothyroidism undergoing treatment to 75 healthy subjects. This research measured periodontal health indicators, thyroid hormone levels, and inflammatory markers. Results indicated that those with autoimmune hypothyroidism experienced more severe periodontal disease and increased periodontal tissue loss. They also showed elevated levels of specific thyroid antibodies and thyroid hormonal imbalances. Importantly, a significant positive association was found between the extent of periodontal tissue loss and these thyroid‐related markers, especially the anti‐TPO antibody. In conclusion, individuals with autoimmune hypothyroidism are at a higher risk for severe periodontal disease, suggesting a relationship between thyroid dysfunction and periodontal health. Therefore, it is crucial for both periodontists and endocrinologists to recognize this association when planning appropriate treatments.
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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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