Ajay Major, Joanne Chou, Helen Lam, Karen E Kim, Lucie M Turcotte, Wendy Leisenring, Yutaka Yasui, Joseph P Neglia, Michael Curry, Rebecca M Howell, Kevin C Oeffinger, David Hodgson, Paul C Nathan, Greg T Armstrong, Chaya S Moskowitz, Tara O Henderson
{"title":"儿童癌症幸存者结直肠癌后的死亡率","authors":"Ajay Major, Joanne Chou, Helen Lam, Karen E Kim, Lucie M Turcotte, Wendy Leisenring, Yutaka Yasui, Joseph P Neglia, Michael Curry, Rebecca M Howell, Kevin C Oeffinger, David Hodgson, Paul C Nathan, Greg T Armstrong, Chaya S Moskowitz, Tara O Henderson","doi":"10.1093/jnci/djaf127","DOIUrl":null,"url":null,"abstract":"Mortality after diagnosis of colorectal subsequent malignant neoplasms (CRC-SMN) among childhood cancer survivors is understudied. Using data from the Childhood Cancer Survivor Study (CCSS) and the Surveillance, Epidemiology, and End Results (SEER) program, we compared all-cause mortality of survivors with CRC-SMN to survivors without CRC-SMN and CRC patients in the general population without a childhood cancer history. Among 25,656 childhood cancer survivors, 96 developed CRC-SMN, with 50% diagnosed before age 40 and 19% before age 30. Of those diagnosed before age 40, 35% had no prior abdominal/pelvic-directed radiation therapy. The cumulative incidence of CRC-SMN in CCSS survivors was 0.7% (95%CI: 0.5%-0.9%) by age 45 and 1.1% (95%CI: 0.8%-1.4%) by age 50. There were 31 deaths after CRC-SMN. Adjusted all-cause mortality was threefold higher (HR 3.34, 95%CI: 2.25-4.59) than for survivors without CRC and significantly higher for survivors diagnosed under age 30 compared to SEER CRC patients (HR 2.51, 95%CI: 1.29-4.89).","PeriodicalId":501635,"journal":{"name":"Journal of the National Cancer Institute","volume":"26 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mortality after colorectal cancer among survivors of childhood cancer\",\"authors\":\"Ajay Major, Joanne Chou, Helen Lam, Karen E Kim, Lucie M Turcotte, Wendy Leisenring, Yutaka Yasui, Joseph P Neglia, Michael Curry, Rebecca M Howell, Kevin C Oeffinger, David Hodgson, Paul C Nathan, Greg T Armstrong, Chaya S Moskowitz, Tara O Henderson\",\"doi\":\"10.1093/jnci/djaf127\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Mortality after diagnosis of colorectal subsequent malignant neoplasms (CRC-SMN) among childhood cancer survivors is understudied. Using data from the Childhood Cancer Survivor Study (CCSS) and the Surveillance, Epidemiology, and End Results (SEER) program, we compared all-cause mortality of survivors with CRC-SMN to survivors without CRC-SMN and CRC patients in the general population without a childhood cancer history. Among 25,656 childhood cancer survivors, 96 developed CRC-SMN, with 50% diagnosed before age 40 and 19% before age 30. Of those diagnosed before age 40, 35% had no prior abdominal/pelvic-directed radiation therapy. The cumulative incidence of CRC-SMN in CCSS survivors was 0.7% (95%CI: 0.5%-0.9%) by age 45 and 1.1% (95%CI: 0.8%-1.4%) by age 50. There were 31 deaths after CRC-SMN. Adjusted all-cause mortality was threefold higher (HR 3.34, 95%CI: 2.25-4.59) than for survivors without CRC and significantly higher for survivors diagnosed under age 30 compared to SEER CRC patients (HR 2.51, 95%CI: 1.29-4.89).\",\"PeriodicalId\":501635,\"journal\":{\"name\":\"Journal of the National Cancer Institute\",\"volume\":\"26 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the National Cancer Institute\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/jnci/djaf127\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the National Cancer Institute","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/jnci/djaf127","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mortality after colorectal cancer among survivors of childhood cancer
Mortality after diagnosis of colorectal subsequent malignant neoplasms (CRC-SMN) among childhood cancer survivors is understudied. Using data from the Childhood Cancer Survivor Study (CCSS) and the Surveillance, Epidemiology, and End Results (SEER) program, we compared all-cause mortality of survivors with CRC-SMN to survivors without CRC-SMN and CRC patients in the general population without a childhood cancer history. Among 25,656 childhood cancer survivors, 96 developed CRC-SMN, with 50% diagnosed before age 40 and 19% before age 30. Of those diagnosed before age 40, 35% had no prior abdominal/pelvic-directed radiation therapy. The cumulative incidence of CRC-SMN in CCSS survivors was 0.7% (95%CI: 0.5%-0.9%) by age 45 and 1.1% (95%CI: 0.8%-1.4%) by age 50. There were 31 deaths after CRC-SMN. Adjusted all-cause mortality was threefold higher (HR 3.34, 95%CI: 2.25-4.59) than for survivors without CRC and significantly higher for survivors diagnosed under age 30 compared to SEER CRC patients (HR 2.51, 95%CI: 1.29-4.89).
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