在PennPET Explorer上临床活动水平的高分辨率正电子终身断层扫描

Bangyan Huang, Bing Dai, Suzanne E. Lapi, Grace Liles, Joel S. Karp, Jinyi Qi
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引用次数: 0

摘要

本研究的目的是利用与人体成像相关的多种放射性同位素的活动水平的三维幻影演示高分辨率正电子寿命断层扫描。方法:以6 mm厚的聚碳酸酯板为中心植入圆柱体。用高灵敏度的长轴视场扫描仪PennPET Explorer扫描仪对假体填充放射性溶液进行扫描。用3种不同放射性同位素(82Rb (240 MBq)、68Ga (110 MBq)和44Sc(7.4和40.7 MBq)进行了4次扫描。对随机事件进行校正后重建了平均正电子寿命图像。径向和轴向分辨率分别从横跨板上的孔和穿过板的寿命剖面测量。结果:聚碳酸酯板在所有正电子寿命重建图像中都是可分辨的,其正电子寿命比在水中长。来自82Rb和68Ga的寿命图像由于其低提示γ产率和高随机分数而具有噪声,而在44Sc图像中噪声大大降低。4次扫描的平均寿命估计值是一致的。估计径向和轴向分辨率分别为3.7±1.8 mm和3.9±0.4 mm。结论:本研究成功证明了在PennPET Explorer上使用82Rb、68Ga和44Sc进行高分辨率正电子寿命层析成像的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-Resolution Positronium Lifetime Tomography at Clinical Activity Levels on the PennPET Explorer

The objective of this study is to demonstrate high-resolution positronium lifetime tomography using a 3-dimensional phantom with multiple radioisotopes at activity levels relevant to human imaging. Methods: A cylinder phantom was constructed with a 6-mm thick polycarbonate slab inserted at its center. The phantom was filled with radioactive solutions and scanned in the PennPET Explorer scanner, a long–axial-field-of-view scanner with high sensitivity. Four scans were conducted with 3 different radioisotopes at varying activity levels: 82Rb (240 MBq), 68Ga (110 MBq), and 44Sc (7.4 and 40.7 MBq). The average positron lifetime images were reconstructed with correction for random events. Radial and axial resolutions were measured from lifetime profiles across a hole on the slab and through the slab, respectively. Results: The polycarbonate slab was resolvable in all reconstructed positron lifetime images and showed a lifetime longer than that in water. The lifetime images from 82Rb and 68Ga were noisy because of their low prompt γ yields and high random fractions, whereas noise was substantially reduced in the 44Sc images. The average lifetime estimates were consistent across the 4 scans. The estimated radial and axial resolutions were 3.7 ± 1.8 mm and 3.9 ± 0.4 mm, respectively. Conclusion: This study successfully demonstrated the feasibility of high-resolution positronium lifetime tomography using 82Rb, 68Ga, and 44Sc on the PennPET Explorer.

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