Bangyan Huang, Bing Dai, Suzanne E. Lapi, Grace Liles, Joel S. Karp, Jinyi Qi
{"title":"在PennPET Explorer上临床活动水平的高分辨率正电子终身断层扫描","authors":"Bangyan Huang, Bing Dai, Suzanne E. Lapi, Grace Liles, Joel S. Karp, Jinyi Qi","doi":"10.2967/jnumed.125.270130","DOIUrl":null,"url":null,"abstract":"<p>The objective of this study is to demonstrate high-resolution positronium lifetime tomography using a 3-dimensional phantom with multiple radioisotopes at activity levels relevant to human imaging. <strong>Methods:</strong> A cylinder phantom was constructed with a 6-mm thick polycarbonate slab inserted at its center. The phantom was filled with radioactive solutions and scanned in the PennPET Explorer scanner, a long–axial-field-of-view scanner with high sensitivity. Four scans were conducted with 3 different radioisotopes at varying activity levels: <sup>82</sup>Rb (240 MBq), <sup>68</sup>Ga (110 MBq), and <sup>44</sup>Sc (7.4 and 40.7 MBq). The average positron lifetime images were reconstructed with correction for random events. Radial and axial resolutions were measured from lifetime profiles across a hole on the slab and through the slab, respectively. <strong>Results:</strong> The polycarbonate slab was resolvable in all reconstructed positron lifetime images and showed a lifetime longer than that in water. The lifetime images from <sup>82</sup>Rb and <sup>68</sup>Ga were noisy because of their low prompt γ yields and high random fractions, whereas noise was substantially reduced in the <sup>44</sup>Sc images. The average lifetime estimates were consistent across the 4 scans. The estimated radial and axial resolutions were 3.7 ± 1.8 mm and 3.9 ± 0.4 mm, respectively. <strong>Conclusion:</strong> This study successfully demonstrated the feasibility of high-resolution positronium lifetime tomography using <sup>82</sup>Rb, <sup>68</sup>Ga, and <sup>44</sup>Sc on the PennPET Explorer.</p>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":"27 1","pages":"jnumed.125.270130"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High-Resolution Positronium Lifetime Tomography at Clinical Activity Levels on the PennPET Explorer\",\"authors\":\"Bangyan Huang, Bing Dai, Suzanne E. Lapi, Grace Liles, Joel S. Karp, Jinyi Qi\",\"doi\":\"10.2967/jnumed.125.270130\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The objective of this study is to demonstrate high-resolution positronium lifetime tomography using a 3-dimensional phantom with multiple radioisotopes at activity levels relevant to human imaging. <strong>Methods:</strong> A cylinder phantom was constructed with a 6-mm thick polycarbonate slab inserted at its center. The phantom was filled with radioactive solutions and scanned in the PennPET Explorer scanner, a long–axial-field-of-view scanner with high sensitivity. Four scans were conducted with 3 different radioisotopes at varying activity levels: <sup>82</sup>Rb (240 MBq), <sup>68</sup>Ga (110 MBq), and <sup>44</sup>Sc (7.4 and 40.7 MBq). The average positron lifetime images were reconstructed with correction for random events. Radial and axial resolutions were measured from lifetime profiles across a hole on the slab and through the slab, respectively. <strong>Results:</strong> The polycarbonate slab was resolvable in all reconstructed positron lifetime images and showed a lifetime longer than that in water. The lifetime images from <sup>82</sup>Rb and <sup>68</sup>Ga were noisy because of their low prompt γ yields and high random fractions, whereas noise was substantially reduced in the <sup>44</sup>Sc images. The average lifetime estimates were consistent across the 4 scans. The estimated radial and axial resolutions were 3.7 ± 1.8 mm and 3.9 ± 0.4 mm, respectively. <strong>Conclusion:</strong> This study successfully demonstrated the feasibility of high-resolution positronium lifetime tomography using <sup>82</sup>Rb, <sup>68</sup>Ga, and <sup>44</sup>Sc on the PennPET Explorer.</p>\",\"PeriodicalId\":22820,\"journal\":{\"name\":\"The Journal of Nuclear Medicine\",\"volume\":\"27 1\",\"pages\":\"jnumed.125.270130\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Nuclear Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2967/jnumed.125.270130\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Nuclear Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2967/jnumed.125.270130","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
High-Resolution Positronium Lifetime Tomography at Clinical Activity Levels on the PennPET Explorer
The objective of this study is to demonstrate high-resolution positronium lifetime tomography using a 3-dimensional phantom with multiple radioisotopes at activity levels relevant to human imaging. Methods: A cylinder phantom was constructed with a 6-mm thick polycarbonate slab inserted at its center. The phantom was filled with radioactive solutions and scanned in the PennPET Explorer scanner, a long–axial-field-of-view scanner with high sensitivity. Four scans were conducted with 3 different radioisotopes at varying activity levels: 82Rb (240 MBq), 68Ga (110 MBq), and 44Sc (7.4 and 40.7 MBq). The average positron lifetime images were reconstructed with correction for random events. Radial and axial resolutions were measured from lifetime profiles across a hole on the slab and through the slab, respectively. Results: The polycarbonate slab was resolvable in all reconstructed positron lifetime images and showed a lifetime longer than that in water. The lifetime images from 82Rb and 68Ga were noisy because of their low prompt γ yields and high random fractions, whereas noise was substantially reduced in the 44Sc images. The average lifetime estimates were consistent across the 4 scans. The estimated radial and axial resolutions were 3.7 ± 1.8 mm and 3.9 ± 0.4 mm, respectively. Conclusion: This study successfully demonstrated the feasibility of high-resolution positronium lifetime tomography using 82Rb, 68Ga, and 44Sc on the PennPET Explorer.