多系统萎缩中皮肤微生物组的改变：一项初步研究

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-08-23 DOI:10.1038/s41531-025-01121-w

Daji Chen, Lang Sun, Linlin Wan, Zhao Chen, LinLiu Peng, Jinzi Peng, Riwei Ouyang, Xiafei Long, Kefang Du, Xiao Dong, Xiaokang Wu, Xinying Xiao, Ruqing He, Rong Qiu, Beisha Tang, Hong Jiang

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引用次数: 0

摘要

多系统萎缩（MSA）改变皮肤生理，潜在地影响皮肤微生物群。这项初步研究调查了皮肤微生物群在MSA中是否存在差异，以及这些差异是否与疾病严重程度有关。通过对MSA、帕金森病患者和对照组的宫颈和腋窝部位进行16S rRNA测序，我们发现了组间不同的微生物模式。这些模式允许队列分类，并显示与临床症状密切相关，提示MSA中与疾病相关的微生物改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Alterations of the skin microbiome in multiple system atrophy: a pilot study

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Alterations of the skin microbiome in multiple system atrophy: a pilot study

Multiple system atrophy (MSA) alters skin physiology, potentially impacting skin microbiota. This pilot study investigated whether skin microbiota differs in MSA and whether these differences relate to disease severity. Using 16S rRNA sequencing of cervical and axillary sites in MSA, Parkinson’s disease, and controls, we identified distinct microbial patterns among groups. These patterns allowed cohort classification and showed strong associations with clinical symptoms, suggesting disease-related microbial alterations in MSA.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.