An Alternative Method for the Efficient Synthesis of Aminoindane-Based Chiral Triazolium Salts

A list of functionalized aminoindane-based chiral triazolium salts has been prepared from readily available 1-amino-2-indanol via a new method in the presence of Im₂CS, H₂O₂, and HBF₄. Over the years, Rovis, Bode, Suzuki, and Scheidt et al. developed a method for preparing chiral thiazolium salts using Meerwein's reagent (Me₃OBF₄) arylhydrazine, and excess amounts of (EtO)₃CH as key reagent and the reaction proceeded at high temperature. We report alternative methods to access chiral triazolium salts with better yields (67%–87%), clean reaction, mild reaction conditions and ambient temperature, operational simplicity, a simple purification process, and tolerating a wide range of functional groups.