肺癌管理的临床策略:来自2024年弥合差距肺癌共识会议的建议

IF 5.1 2区 医学 Q1 ONCOLOGY
Cancer Pub Date : 2025-08-26 DOI:10.1002/cncr.70060
Narjust Florez MD, Sandip Patel MD, Heather A. Wakelee MD, Julia Rotow MD, Elaine Shum MD, Jacob Sands MD, Ravi Salgia MD, PhD, Fred R. Hirsch MD, PhD, Solange Peters MD, PhD, Joshua Sabari MD, Hatim Husain MD, Lyudmila Bazhenova MD, Erminia Massarelli MD, PhD, MS, Leah M. Backhus MD, MPH, Percy Lee MD, Roy S. Herbst MD, PhD, Christine Bestvina MD, Kristin Higgins MD, Aakash Desai MD, MPH, Martin Dietrich MD, PhD, Hari Balaji Keshava MD, MS, Balazs Halmos MD, MS, David R. Gandara MD, Jonathan Wesley Riess MD, MS, Ana I. Velázquez MD, MSc, Anjali Sibley MD, MPH, Misty Shields MD, PhD, Triparna Sen PhD, MS, Edward S. Kim MD, MBA
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引用次数: 0

摘要

非小细胞肺癌(NSCLC)和小细胞肺癌的临床实践指南包括基于高水平临床试验证据的建议,但在现实世界的实践中经常看到复杂的临床问题,而这些问题并没有得到前瞻性试验数据的明确回答。为了解决这些问题,2024年弥合差距肺癌共识会议(BtG LCCC 2024)召开,为缺乏1级证据的临床情况制定以美国为重点的专家指南。在BtG LCCC 2024上,一个多学科专家小组讨论了小细胞肺癌管理、egfr突变非小细胞肺癌的靶向治疗、早期非小细胞肺癌的管理、非egfr癌基因驱动非小细胞肺癌的识别和管理以及晚期/转移性非小细胞肺癌的免疫治疗。通过使用改进的德尔菲过程,制定了12项共识建议,目的是为临床医生管理肺癌的新诊断方法和治疗方法的使用提供指导。本报告回顾了这些达成共识的领域,并讨论了如何应用当前临床证据的持续问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical strategies for lung cancer management: Recommendations from the Bridging the Gaps Lung Cancer Consensus Conference 2024

Clinical practice guidelines for nonsmall cell lung cancer (NSCLC) and small cell lung cancer include recommendations based on high-level clinical trial evidence, but complex clinical questions are frequently seen in real-world practice that are not clearly answered by prospective trial data. To address these questions, the Bridging the Gaps Lung Cancer Consensus Conference 2024 (BtG LCCC 2024) convened to develop US-focused expert guidance for clinical situations in which level 1 evidence is lacking. At BtG LCCC 2024, a multidisciplinary expert panel discussed ongoing clinical issues in small cell lung cancer management, targeted therapy in EGFR-mutated NSCLC, management of early stage NSCLC, identification and management of non-EGFR oncogene-driven NSCLC, and use of immunotherapy in advanced/metastatic NSCLC. By using a modified Delphi process, 12 consensus recommendations were developed with the goal of providing guidance on the use of novel diagnostic methods and treatments for clinicians who manage lung cancer. This report reviews these areas of consensus and discusses ongoing questions about ways to apply current clinical evidence.

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来源期刊
Cancer
Cancer 医学-肿瘤学
CiteScore
13.10
自引率
3.20%
发文量
480
审稿时长
2-3 weeks
期刊介绍: The CANCER site is a full-text, electronic implementation of CANCER, an Interdisciplinary International Journal of the American Cancer Society, and CANCER CYTOPATHOLOGY, a Journal of the American Cancer Society. CANCER publishes interdisciplinary oncologic information according to, but not limited to, the following disease sites and disciplines: blood/bone marrow; breast disease; endocrine disorders; epidemiology; gastrointestinal tract; genitourinary disease; gynecologic oncology; head and neck disease; hepatobiliary tract; integrated medicine; lung disease; medical oncology; neuro-oncology; pathology radiation oncology; translational research
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