L. L. Nikolaeva, E. V. Sanarova, A. P. Kolpaksidi, S. D. Shcheglov, A. A. Rudakova, M. A. Baryshnikova, N. G. Preferanskaya, I. G. Meerovich, A. V. Lantsova
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Development and Study of the Properties of Polymeric Submicron Particles of Gefitinib with Photoinduced Release
Currently, studies aimed at creating stimulus-sensitive nanostructured and microstructured drugs, in which the release of a chemotherapeutic agent occurs in a controlled manner under the effect of a certain stimulus, are widespread. This study is devoted to the creation of a polymer model of gefitinib with photoinduced release due to the inclusion of a photosensitizer in the dosage form. The obtained samples are characterized by a particle diameter of up to 150 nm with a rather narrow size distribution. A study of the cytotoxic activity of polymer particles under photoexposure reveals a combined effect of gefitinib and the photosensitizer, with the cytotoxic activity of the samples exceeding the effect of free gefitinib by 1.4–1.7 times.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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