N. A. Tagandurdyeva, G. V. Vaganov, I. P. Dobrovol’skaya, E. N. Dresvyanina, E. N. Popova, V. Yu. Elokhovskiy, V. E. Yudin, T. Wang
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Development of Resorbible Composites Based on Chitosan Fibers for Bone Grafting
A method for producing composite materials for cranioplasty based on polylactide and poly-ε-caprolactone, which contain chitosan threads as a reinforcing filler, is described. Chitosan threads are obtained via wet spinning by precipitating acetic acid solutions of chitosan in an alcohol-alkaline medium. The melting temperatures of polylactide and poly-ε-caprolactone are significantly lower than the degradation temperature of chitosan, which makes it possible to obtain composite materials using heat-treatment methods, e.g., calendering and pressing. The composite material based on polylactide has strength and elastic characteristics close to those of cancellous bone tissue, and the composite based on poly-ε-caprolactone has those of cortical bone. This allows us to recommend the obtained composite materials for preclinical and clinical studies as bone-tissue implants, in pediatric cranioplasty for the treatment of injuries and diseases of the skull bones.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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