银离子防腐治疗作用机理研究

IF 0.8 Q3 Engineering
A. A. Antsiferova, P. K. Kashkarov
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引用次数: 0

摘要

银制品的杀菌作用机制的概念,在世界科学界是广为人知的,可以归结为抑制和破坏有害的细菌、病毒和真菌。例如,这是由于氧化应激引起的病原体(细菌、真菌)的死亡,这是由于银离子影响细胞呼吸途径时活性氧的产生增加而引起的。然而,这种机制同样会导致体内有益细菌和健康细胞的死亡,这与几个世纪以来将银化合物用于医疗目的的历史相矛盾。这篇综述提出了银离子治疗性抗菌作用的一种根本不同的机制:诱导应激,应激反过来对身体产生刺激作用,激活其自身资源(类似于转化性心理跑步、冷暴露和桑拿使用)。暴露于银离子时产生压力的原因是,银对哺乳动物来说不是必需的(生命的)元素,也不是经常存在于体内,因此身体被迫适应银离子,就像暴露于银离子时出现的新扰动一样。为了确保治疗效果,有必要的是,压力影响的持续时间和强度不要太大,以避免慢性压力和痛苦,这是众所周知的,导致抑制身体的重要资源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
On the Mechanism of the Antiseptic Therapeutic Action of Silver Ions

The concepts of the mechanisms of the antiseptic action of silver preparations, which are widely known in the world scientific community, can be boiled down to the suppression and destruction of harmful bacteria, viruses, and fungi. For example, this is the death of pathogens (bacteria, fungi) due to oxidative stress, which is caused by the increased generation of reactive oxygen species when silver ions affect the cell respiration pathway. However, this mechanism could equally lead to the death of beneficial bacteria and healthy cells in the body, which contradicts the centuries-old history of using silver compounds for medical purposes. The review puts forward the idea of a fundamentally different mechanism of the therapeutic antiseptic action of silver ions: the induction of stress, which, in turn, has a stimulating effect on the body, activating its own resources (similar to transformational psychological running, cold exposure, and sauna use). The occurrence of stress during exposure to silver ions is explained by the fact that silver is not an essential (vital) element for mammals, is not constantly present in the body, and thus the body is forced to adapt to it as to the novel perturbance during such exposure. In order to ensure a therapeutic effect, it is necessary that the duration and intensity of the stressful impact not be too great to avoid chronic stress and distress, which, as is known, lead to suppression of the body’s vital resources.

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来源期刊
Nanotechnologies in Russia
Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
1.20
自引率
0.00%
发文量
0
期刊介绍: Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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