含有烷基三芳基磷片段的3-芳基-1-吡咯啉盐的非对映特异性环化：合成新的吡咯利嗪衍生物的途径

IF 2.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

New Journal of Chemistry Pub Date : 2025-08-08 DOI:10.1039/D5NJ02552D

Tanzilya Rizbayeva, Andrey Smolobochkin, Almir Gazizov, Olga Babaeva, Anna Lyubina, Anastasiia Sapunova, Alexandra Voloshina, Daria Gerasimova, Alexander Burilov and Michail Pudovik

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引用次数: 0

摘要

本文报道了一种非对映特异性合成含烷基三苯基磷酸盐片段的3-芳基-1-吡咯啉衍生物的方法，该方法在乙磺酸钠和水催化下进行环化。得到了一些新的含磷吡咯烷类化合物，产率达99%。得到了实验数据，揭示了该反应机理的细节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Diastereospecific cyclization of 3-arylidene-1-pyrrolinium salts containing an alkyltriarylphosphonium fragment: a path to the synthesis of new pyrrolizidine derivatives

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Diastereospecific cyclization of 3-arylidene-1-pyrrolinium salts containing an alkyltriarylphosphonium fragment: a path to the synthesis of new pyrrolizidine derivatives

We report a diastereospecific method for the synthesis of phosphorus-containing pyrrolizidines based on the cyclization of 3-arylidene-1-pyrrolinium derivatives containing an alkyltriphenylphosphonium salt fragment catalyzed by sodium ethylate and water. A number of new phosphorus-containing pyrrolizidines were obtained with product yields reaching 99%. Experimental data were obtained, revealing the details of the mechanism of this reaction.

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