神经退行性疾病的表转录组失调及其对疾病病理和机制的影响

IF 4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Neurochemistry international Pub Date : 2025-08-20 DOI:10.1016/j.neuint.2025.106037

Andrew M. Shafik, Peng Jin

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引用次数: 0

摘要

RNA修饰，统称为表转录组，在调节RNA代谢中起着至关重要的作用，影响着剪接、稳定性、定位和翻译等关键过程。现在越来越多的证据表明，表转录组失调与神经退行性疾病有关。在这篇综述中，我们重点介绍了四种RNA修饰及其对神经退行性通路的影响，包括突触功能、神经炎症信号和应激颗粒的形成。这些发现强调了RNA修饰在神经变性中发挥的复杂和多方面的作用，强调了它们作为生物标志物和治疗靶点的新兴潜力。

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Epitranscriptomic dysregulation in neurodegenerative diseases and its implications for disease pathology and mechanisms

RNA modifications, collectively referred to as the epitranscriptome, play a crucial role in regulating RNA metabolism, influencing key processes such as splicing, stability, localization, and translation. Increasing evidence now links dysregulation of the epitranscriptome to neurodegenerative diseases. In this review, we focus on four RNA modifications and their influence on neurodegenerative pathways, including synaptic function, neuroinflammatory signaling, and stress granule formation. These findings highlight the complex and multifaceted roles that RNA modifications play in neurodegeneration, emphasizing their emerging potential as biomarkers and therapeutic targets.

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来源期刊

Neurochemistry international 医学-神经科学

CiteScore

8.40

自引率

2.40%

发文量

128

审稿时长

37 days

期刊介绍： Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.